About: Methylprednisolone

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A prednisolone derivative with similar anti-inflammatory action. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B43CE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43CF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43E0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43E1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43E2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43E3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43E4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43DE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B43D5-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16042225 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1-3 hours (en)
http://linked.open...ugbank/indication	Adjunctive therapy for short-term administration in rheumatoid arthritis. (en)
http://linked.open...bank/manufacturer	Barr laboratories inc Barr Pharmaceuticals GlaxoSmithKline Inc. Hospira inc DSM Corp. Global Pharmaceuticals Heartland Repack Services LLC Alra laboratories inc Kaiser Foundation Hospital Abbott laboratories hosp products div Elkins sinn div ah robins co inc Sandoz Abraxis pharmaceutical products Sandoz Bedford laboratories International medication systems ltd Barr laboratories inc Corepharma LLC
sameAs	Methylprednisolone
Title	Methylprednisolone (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/chebi/6888 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/chemspider/6485 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/drugbank/DB00959 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/kegg-drug/D00407 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/national-drug-code-directory/0555-0301-02 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/pharmgkb/PA450466 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/pubchem-compound/6741 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/pubchem-substance/46504885 http://linked.opendata.cz/resource/drugbank/drug/DB00959/identifier/wikipedia/Methylprednisolone
http://linked.open...mechanismOfAction	Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. APP Pharmaceuticals Roche DAVA Pharmaceuticals Centocor Ortho Biotech Inc. A-S Medication Solutions LLC Amerisource Health Services Corp. Bedford Labs Cardinal Health Bristol myers squibb pharma co Cubist Pharmaceuticals Inc. Abbott laboratories pharmaceutical products div Aidarex Pharmacuticals LLC A-S Medication Solutions LLC Atlantic Biologicals Corporation Barr Pharmaceuticals Blenheim Pharmacal Bristol-Myers Squibb Co. Cadila Healthcare Ltd. Cardinal Health Caremark LLC Clint Pharmaceutical Inc. Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. DRX Pharmaceuticals General Injectables and Vaccines Inc. Greenstone LLC H.J. Harkins Co. Inc. Lake Erie Medical and Surgical Supply Hospira Inc. Innoviant Pharmacy Inc. Major Pharmaceuticals Merrell Pharmaceuticals Inc. Amerisource Health Services Corp. Advanced Pharmaceutical Services Inc. Neuman Distributors Inc. Pharmaceutical Utilization Management Program VA Inc. Eli lilly and co Abbott laboratories pharmaceutical products div

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