About: Isoniazid

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B415F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4160-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4161-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4162-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4163-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Fast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours. (en)
http://linked.open...ugbank/indication	For the treatment of all forms of tuberculosis in which organisms are susceptible. (en)
http://linked.open...bank/manufacturer	Bayer Healthcare Allergan inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Eli lilly and co Mk laboratories inc Solstice Neurosciences Mutual pharmaceutical co inc Nexgen pharma inc Panray corp sub ormont drug and chemical co inc L perrigo co Pharmavite pharmaceuticals Merck & Co. Patheon Inc. Watson laboratories inc West ward pharmaceutical corp Dr reddys laboratories ltd Hikma pharmaceuticals Ivax pharmaceuticals inc sub teva pharmaceuticals usa Mylan pharmaceuticals inc Mikart inc Lannett co inc Ranbaxy pharmaceuticals inc APP Pharmaceuticals Ben Venue Laboratories Inc. Barr laboratories inc JHP Pharmaceuticals LLC Amerisource Health Services Corp. Banner Pharmacaps Inc.
sameAs	Isoniazid
Title	Isoniazid (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/chebi/6030 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/chemspider/3635 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/drugbank/DB00951 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/kegg-compound/C07054 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/kegg-drug/D00346 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/national-drug-code-directory/0555-0066-02 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/pdb/ISZ http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/pharmgkb/PA450112 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/pubchem-compound/3767 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/pubchem-substance/46506039 http://linked.opendata.cz/resource/drugbank/drug/DB00951/identifier/wikipedia/Isoniazid
http://linked.open...mechanismOfAction	Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular <i>Mycobacterium tuberculosis</i> organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from <i>Mycobacterium tuberculosis</i>, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Bayer healthcare pharmaceuticals inc Bayer pharmaceuticals corp Amgen Inc. Acs dobfar info sa Baxter healthcare corp Bedford Labs Eli Lilly & Co. Sandoz Depomed inc Aurobindo pharma ltd Advanced Pharmaceutical Services Inc. Sandoz Amend Amneal Pharmaceuticals Apotheca Inc. Barr Pharmaceuticals Amerisource Health Services Corp. Aurobindo Pharma Ltd. Ben Venue Laboratories Inc. Cadila Healthcare Ltd. Consolidated Midland Corp. Dept Health Central Pharmacy Direct Dispensing Inc. Dispensing Solutions App pharmaceuticals llc Bedford laboratories Claris lifesciences ltd Hospira inc Sandoz Major Pharmaceuticals PCA LLC Alcon inc Akorn inc Bausch and lomb pharmaceuticals inc Preferred Pharmaceuticals Inc. Aurobindo pharma ltd Prepak Systems Inc. Barr laboratories inc Carlsbad technology inc Apotex inc
http://linked.open...outeOfElimination	From 50 to 70 percent of a dose of isoniazid is excreted in the urine within 24 hours. (en)
http://linked.open.../drugbank/synonym	Isoniazid (en) INH (en) Isonicotinic acid hydrazide (en) Isonicotinic hydrazide (en) Isonicotinohydrazide (en) Isonicotinylhydrazine (en)

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