About: Diethylpropion

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3ED1-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Adan RA, Vanderschuren LJ, la Fleur SE: Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci. 2008 Apr;29(4):208-17. Epub 2008 Mar 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18353447 # Arias HR, Santamaria A, Ali SF: Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion. Int Rev Neurobiol. 2009;88:223-55. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19897080 (en)
http://linked.open...gy/drugbank/group	approved (en) illicit (en)
http://linked.open...drugbank/halfLife	Using a phosphorescence assay that is specific for basic compounds containing benzoyl group, the plasma half-life of the aminoketone metabolites is estimated to be between 4 to 6 hours. (en)
http://linked.open...ugbank/indication	Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. (en)
http://linked.open...bank/manufacturer	Atlantic Biologicals Corporation Barr Pharmaceuticals 3m pharmaceuticals inc Cardinal Health Pfizer Inc. Comprehensive Consultant Services Inc. Corepharma LLC Dept Health Central Pharmacy DHHS Program Support Center Supply Service Center
sameAs	Diethylpropion
Title	Diethylpropion (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/chebi/4530 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/chemspider/6762 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/drugbank/DB00937 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/kegg-compound/C06954 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/national-drug-code-directory/64720-208-10 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/pubchem-compound/7029 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/pubchem-substance/46506622 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/pharmgkb/PA164778098 http://linked.opendata.cz/resource/drugbank/drug/DB00937/identifier/wikipedia/Diethylpropion
http://linked.open...mechanismOfAction	Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Diethylpropion (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that diethylpropion can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage. (en)
http://linked.open...drugbank/packager	Amgen Inc. Boehringer Ingelheim Ltd. Carlisle Laboratories Inc. Corepharma LLC Darby Dental Supply Co. Inc. Dispensing Solutions Amgen Inc. + Wyeth + Takeda Keltman Pharmaceuticals Inc. Lake Erie Medical and Surgical Supply Landmark Chemical Co. Macnary Ltd. GD Searle LLC Pfizer Inc. Patheon Inc. Gd searle llc Physicians Total Care Inc. Preferred Pharmaceuticals Inc. Prepak Systems Inc. Qualitest Aidarex Pharmacuticals LLC Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Apotheca Inc. A-S Medication Solutions LLC
http://linked.open...outeOfElimination	Diethylpropion is rapidly absorbed from the GI tract after oral administration and is extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Diethylpropion and/or its active metabolites are believed to cross the blood-brain barrier and the placenta. Diethylpropion and its metabolites are excreted mainly by the kidney. (en)
http://linked.open.../drugbank/synonym	Amfepramone (en) Diethylpropion (en) Diethylcathinone (en) alpha-Benzoyltriethylamine (en) alpha-Diethylaminopropiophenone (en) (+-)-Diethylpropion (en) (±)-diethylpropion (en) 1-phenyl-2-diethylamino-1-propanone (en) 2-(Diethylamino)-1-phenyl-1-propanone (en) 2-(Diethylamino)propiophenone (en) Amfepramonum (en) Anfepramona (en)
http://linked.open...drugbank/toxicity	The reported oral LD<sub>50</sub> for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg. Manifestation of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-20-92
http://linked.open...k/foodInteraction	Take without regard to meals. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Schutte, J.; U.S. Patent 3,001,910; September 26, 1961; assigned to Firma Ternmler-Werke (W. Germany). (en)
foaf:page	http://www.drugs.com/cdi/diethylpropion.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ten1435.shtml http://www.rxlist.com/cgi/generic3/diethprop.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B3ED6-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B3EDC-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3EDB-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3ED8-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3ED9-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B3EDA-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B3ED4-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B3ED5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3ED2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3EED-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B3ED3-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Amfepramone
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EE2-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EE3-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B3EDD-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B3EDE-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B3EE0-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B3EDF-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EE1-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Diethylpropion is rapidly absorbed from the GI tract after oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	90-84-6 (en)
http://linked.open...drugbank/category	(en)

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