About: Paricalcitol     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 4 to 6 hours (en)
http://linked.open...ugbank/indication
  • For treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4 (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Paricalcitol (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Paricalcitol is a synthetic, biologically active vitamin D analog of calcitriol with modifications to the side chain (D2) and the A (19-nor) ring. Preclinical andin vitro studies have demonstrated that paricalcitol's biological actions are mediated through binding of the VDR, which results in the selective activation of vitamin D responsive pathways. Vitamin D and paricalcitol have been shown to reduce parathyroid hormone levels by inhibiting PTH synthesis and secretion. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open...outeOfElimination
  • Paricalcitol is excreted primarily by hepatobiliary excretion. (en)
http://linked.open.../drugbank/synonym
  • Paricalcitol (en)
  • Zemplar (en)
  • 19-Nor-1alpha,25-dihydroxyvitamin D2 (en)
http://linked.open...umeOfDistribution
  • * 30.8 ± 7.5 L [CKD Stage 5-HD] * 34.9 ± 9.5 L [CKD Stage 5-PD] * 23.8 L [healthy subjects] (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • 99.8% (bound to plasma proteins) (en)
http://linked.open...ynthesisReference
  • Anchel Schwartz, Alexei Ploutno, Koby Wolfman, "Preparation of paricalcitol." U.S. Patent US20070149489, issued June 28, 2007. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
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http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Well absorbed (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 131918-61-1 (en)
http://linked.open...rugbank/clearance
  • * 1.49 +/- 0.60 L/h [chronic kidney disease Stage 5 with hemodialysis] * 1.54 +/- 0.95 L/h [chronic kidney disease Stage 5with peritoneal dialysis] (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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