About: Quinidine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5DB8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5DB9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5DBA-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	6-8 hours (en)
http://linked.open...ugbank/indication	For the treatment of ventricular pre-excitation and cardiac dysrhythmias (en)
http://linked.open...bank/manufacturer	Advanced Pharmaceutical Services Inc. Pfizer Inc. A-S Medication Solutions LLC Apotex Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Blu Pharmaceuticals LLC Bristol-Myers Squibb Co. Cobalt Pharmaceuticals Inc. Deca Pharmaceuticals LLC Ivax pharmaceuticals inc sub teva pharmaceuticals usa Dispensing Solutions Diversified Healthcare Services Inc. Eon Labs Glenmark Generics Ltd. InvaGen Pharmaceuticals Inc. Ivax Pharmaceuticals Amend Baxter International Inc. Pharmaceutical Utilization Management Program VA Inc. Hospira Inc. Banner Pharmacaps Inc. Major Pharmaceuticals Novopharm Ltd. Professional Co. Banner pharmacaps inc Eli lilly and co InvaGen Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc. Lannett co inc Major Pharmaceuticals Murfreesboro Pharmaceutical Nursing Supply Halsey drug co inc Mutual pharmaceutical co inc Nucare Pharmaceuticals Inc. Hoffmann la roche inc Patheon Inc.
sameAs	Quinidine
Title	Quinidine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/chebi/28593 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/chemspider/389880 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/drugbank/DB00908 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/guide-to-pharmacology/2342 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/iuphar/2342 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/kegg-compound/C06527 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/national-drug-code-directory/53489-459-02 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/pharmgkb/PA451209 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/pubchem-compound/441074 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/pubchem-substance/46505356 http://linked.opendata.cz/resource/drugbank/drug/DB00908/identifier/wikipedia/Quinidine
http://linked.open...mechanismOfAction	Quinidine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Quinidine may also act on the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito. (en)
http://linked.open...drugbank/packager	Amend Amerisource Health Services Corp. Apotheca Inc. Consolidated Midland Corp. Direct Dispensing Inc. Dispensing Solutions Avkare Incorporated Bedford laboratories Breckenridge Pharmaceuticals Ancheng Pharma Limited Apotex Inc. Aurobindo pharma ltd Bryant Ranch Prepack Camber Pharmaceuticals Inc. Caraco Pharmaceutical Labs Pharmaceutical Utilization Management Program VA Inc. Corepharma LLC Coupler Enterprises Inc. DAVA Pharmaceuticals Dept Health Central Pharmacy DHHS Program Support Center Supply Service Center Direct Dispensing Inc. Dispensing Solutions Global Pharmaceuticals Golden State Medical Supply Inc.
http://linked.open...outeOfElimination	When the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline. (en)
http://linked.open.../drugbank/synonym	Quinidine (en) Chinidin (en) Conchinin (en) Conquinine (en) Kinidin (en) Pitayine (en) alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (en) 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol (en) (+)-quinidine (en) (8R,9S)-Quinidine (en) CIN-QUIN (en) Chinidinum (en) Quinidina (en) (S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol (en) beta-Quinine (en)

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