About: Aminolevulinic acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006 May;7(5):392-401. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16648043 # Kennedy JC, Marcus SL, Pottier RH: Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results. J Clin Laser Med Surg. 1996 Oct;14(5):289-304. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9612195 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Mean half-life is 0.70 ± 0.18 h after the oral dose and 0.83 ± 0.05 h after the intravenous dose. (en)
http://linked.open...ugbank/indication
  • Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Aminolevulinic acid (en)
adms:identifier
http://linked.open...mechanismOfAction
  • According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT). (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Aminolevulinic acid (en)
  • 5-Aminolevulinic acid (en)
  • ALA (en)
  • Aminolevulinate (en)
  • delta-Aminolevulinic acid (en)
  • 5-ALA (en)
  • 5-Amino-4-oxopentanoate (en)
  • 5-Amino-4-oxovaleric acid (en)
  • 5-Aminolevulinate (en)
  • ALA-PDT (en)
  • DALA (en)
  • delta-ALA (en)
http://linked.open...drugbank/toxicity
  • Solution overdose have not been reported. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • Takashi Ebata, Hiroshi Kawakami, Katsuya Matsumoto, Koshi Koseki, Hajime Matsushita, "Method of preparing an acid additional salt of delta-aminolevulinic acid." U.S. Patent US5284973, issued July, 1974. (en)
foaf:page
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http://linked.open...ugbank/absorption
  • Oral bioavailability is 50-60%. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 106-60-5 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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