| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Wander AH: Long-term use of hydroxypropyl cellulose ophthalmic insert to relieve symptoms of dry eye in a contact lens wearer: case-based experience. Eye Contact Lens. 2011 Jan;37(1):39-44. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21178699 # McDonald M, D'Aversa G, Perry HD, Wittpenn JR, Nelinson DS: Correlating patient-reported response to hydroxypropyl cellulose ophthalmic insert (LACRISERT(R)) therapy with clinical outcomes: tools for predicting response. Curr Eye Res. 2010 Oct;35(10):880-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20858108 # Luchs JI, Nelinson DS, Macy JI: Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. Cornea. 2010 Dec;29(12):1417-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20847657 (en)
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| http://linked.open...gy/drugbank/group
| |
| http://linked.open...ugbank/indication
| - Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
| |
| Title
| - Hydroxypropyl cellulose (en)
|
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Hydroxypropyl cellulose is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is a water-soluble thickener, emulsifier and film-former often used in tablet coating. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces. (en)
|
| http://linked.open.../drugbank/synonym
| - Hydroxypropyl cellulose (en)
- Hydroxypropylmethylcellulose phthalate (en)
- Hypromellose phthtalate (en)
- Hiprolosa (en)
- Hydroxypropylcellulose (en)
- Hyprolose (en)
- Hyprolosum (en)
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| http://linked.open...drugbank/toxicity
| - LD<sub>50</sub>=10200 mg/kg (oral, rat) (en)
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| http://linked.open.../drugbank/mixture
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| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ynthesisReference
| - Seiji Orii, Yukio Sasagawa, Akinori Ito, Maruyama, Hiromi, Yoshiteru Sakai, "Process of producing hydroxypropyl cellulose." U.S. Patent US4292426, issued April, 1964. (en)
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| foaf:page
| |
| http://linked.open...ugbank/absorption
| - Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces. (en)
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| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
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| http://linked.open...drugbank/category
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| http://linked.open...gbank/containedIn
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