About: Fosfomycin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antibiotic produced by Streptomyces fradiae. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4745-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis. (en)
http://linked.open...ugbank/indication	For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of <i>Escherichia coli</i> and <i>Enterococcus faecalis</i>. (en)
http://linked.open...bank/manufacturer	Claris lifesciences ltd
sameAs	Fosfomycin
Title	Fosfomycin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/chemspider/394204 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/drugbank/DB00828 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/kegg-compound/C06454 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/kegg-drug/D04253 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/national-drug-code-directory/0456-4300-08 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/pdb/FCN http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/pubchem-compound/446987 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/pubchem-substance/46506665 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/pharmgkb/PA164748039 http://linked.opendata.cz/resource/drugbank/drug/DB00828/identifier/wikipedia/Fosfomycin
http://linked.open...mechanismOfAction	Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. (en)
http://linked.open...drugbank/packager	Baxter healthcare corp anesthesia and critical care Prepak Systems Inc.
http://linked.open...outeOfElimination	Fosfomycin is excreted unchanged in both urine and feces. (en)
http://linked.open.../drugbank/synonym	Fosfocina (en) Phosphomycin (en) Phosphonomycin (en) FOSFOMYCIN (en) (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid (en) (1R,2S)-Epoxypropylphosphonic acid (en) (2R-cis)-(3-Methyloxiranyl)phosphonic acid (en) 1R-cis-(1,2-Epoxypropyl)phosphonic acid (en) FCM (en) Fosfomicina (en) Fosfomycine (en) Fosfomycinum (en) L-cis-1,2-Epoxypropylphosphonic acid (en) Phosphonemycin (en) cis-(1R,2S)-Epoxypropylphosphonic acid (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>>5 g/kg (rats). Side effects may include diarrhea (en)
http://linked.open...umeOfDistribution	* 136.1 ±44.1 L (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-36-00
http://linked.open...k/foodInteraction	Food decreases Cmax slightly. (en) Take without regard to meals. (en)
http://linked.open...nk/proteinBinding	0% (not bound to plasma proteins) (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Graziano Castaldi, Claudio Giordano, "Process for the preparation of intermediates for the synthesis of fosfomycin." U.S. Patent US4937367, issued March, 1972. (en)
foaf:page	http://www.drugs.com/cdi/fosfomycin.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mon1275.shtml http://www.rxlist.com/cgi/generic2/fosfomycin.htm
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4750-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B474F-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B474C-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B474D-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B474E-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4760-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4748-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4747-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Fosfomycin
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4756-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4757-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B4751-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B4752-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B4754-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B4753-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B4755-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30% (en)
http://linked.open.../affectedOrganism	Enteric bacteria and other eubacteria (en)
http://linked.open...casRegistryNumber	23155-02-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 16.9 +/- 3.5 L/hr (en)
http://linked.open...gbank/containedIn	Viramune 200 mg tablet Monurol 3 gm sachet Monurol 3 gm Packets
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B475C-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B475E-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B475F-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4761-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B475B-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B475A-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B475D-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B474B-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4758-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4759-363D-11E5-9242-09173F13E4C5

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