| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open.../drugbank/synonym
| - Defiltran (en)
- Diacarb (en)
- Diamox (en)
- Diluran (en)
- Glaupax (en)
- Acetazolamid (en)
- N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide (en)
- N-[5-(Aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide (en)
- 2-acetylamino-1,3,4-Thiadiazole-5-sulfonamide (en)
- 5-ACETAMIDO-1,3,4-thiadiazole-2-sulfonamide (en)
- 5-acetylamino-1,3,4-Thiadiazole-2-sulfonamide (en)
- Acetazolamida (en)
- Acetazolamidum (en)
- Acétazolamide (en)
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| http://linked.open.../drug/hasAHFSCode
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| http://linked.open...k/foodInteraction
| - Drink plenty of liquids. (en)
- Take with food; at least 6 hours before bedtime. (en)
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| http://linked.open...nk/proteinBinding
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| http://linked.open...ogy/drugbank/salt
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| http://linked.open...ynthesisReference
| - Angela C. Potts, Mark Gibson, "Stable ophthalmic preparations containing acetazolamide." U.S. Patent US4888168, issued August, 1981. (en)
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
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| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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