| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822) (en)
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| http://linked.open...gy/drugbank/group
| |
| http://linked.open...ugbank/indication
| - For the treatment of backache and ankylosing spondylitis (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Phenylbutazone (en)
- Fenilbutazona (en)
- Phenbutazone (en)
- Phenylbutazonum (en)
- 3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine (en)
- 4-BUTYL-1,2-diphenyl-pyrazolidine-3,5-dione (en)
- 4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione (en)
- Phenylbutazon (en)
|
| http://linked.open...drugbank/toxicity
| - Oral, LD<sub>50</sub> = 238 mg/kg (mouse); Oral, LD<sub>50</sub> = 781 mg/kg (rabbit); Oral, LD<sub>50</sub> = 245 mg/kg (rat); Oral, LD<sub>50</sub> = 375 mg/kg (rat) (en)
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| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Take with food to reduce irritation. Avoid alcohol. (en)
|
| http://linked.open.../drugbank/mixture
| |
| http://linked.open...ynthesisReference
| - Dieter Rahtz, Henning Koch, Erich Gerhards, "Hydroxy phenylbutazone derivatives and their preparation." U.S. Patent US3968219, issued January, 1971. (en)
|
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...logy/drugbank/pKa
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
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| http://linked.open...nk/MDDR-Like-Rule
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| http://linked.open...ank/Melting-Point
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| http://linked.open...k/Number-of-Rings
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| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...strongest-acidic-
| |
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