About: Pentoxifylline

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3FFB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3FFC-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# : European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 1996;36(5):315-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8864715 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	0.4-0.8 hours (en)
http://linked.open...ugbank/indication	For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs. (en)
http://linked.open...bank/manufacturer	Actavis elizabeth llc Apotex inc Biovail laboratories inc Heritage pharmaceuticals inc Impax laboratories inc Midlothian Labs Sandoz Murfreesboro Pharmaceutical Nursing Supply St Mary's Medical Park Pharmacy Genzyme Inc. Nephron Pharmaceuticals Corp.
sameAs	Pentoxifylline
Title	Pentoxifylline (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/bindingdb/10850 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/chemspider/4578 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/drugbank/DB00806 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/kegg-compound/C07424 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/kegg-drug/D00501 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/national-drug-code-directory/0378-0357-01 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/pubchem-compound/4740 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/pubchem-substance/46505940 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/pharmgkb/PA450864 http://linked.opendata.cz/resource/drugbank/drug/DB00806/identifier/wikipedia/Pentoxifylline
http://linked.open...mechanismOfAction	Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist. (en)
http://linked.open...drugbank/packager	Baxter healthcare corp anesthesia and critical care Amneal Pharmaceuticals Apotex Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Biovail Pharmaceuticals Cardinal Health Dept Health Central Pharmacy Dispensing Solutions Diversified Healthcare Services Inc. Falcon Pharmaceuticals Ltd. Gayheart Pharmaceutical Inc. Gentex Pharma LLC Gil Pharmaceutical Corp. Gm Pharmaceuticals Inc. Great Southern Laboratories Hawthorn Pharmaceuticals Baxter International Inc. Hospira Inc. Hospira Inc. International Ethical Labs Inc. Patheon Inc. Iopharm Laboratories Inc. Irisys Inc. Jaymac Pharmaceuticals LLC Pfizer Inc. Kylemore Pharmaceuticals Pharmaceutical Utilization Management Program VA Inc. Larken Laboratories Inc. Laser Pharmaceuticals Luitpold Pharmaceuticals Inc. Lunsco Inc. A-S Medication Solutions LLC BASF Corp. Excellium Pharmaceutical Inc. MCR American Pharmaceuticals Inc.
http://linked.open...outeOfElimination	Excretion is almost totally urinary; the main biotransformation product is Metabolite V. Essentially no parent drug is found in the urine. (en)
http://linked.open.../drugbank/synonym	Pentoxifylline (en) Oxpentifylline (en) Pentoxifyllin (en) Pentoxil (en) Trental (en) Pentoxifilina (en) Pentoxifyllinum (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>=1385 mg/kg(orally in mice) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-24-00
http://linked.open...k/foodInteraction	Take with food to reduce irritation. Limit caffeine intake. (en)
http://linked.open.../drugbank/mixture	Tri-Plen
http://linked.open...nk/proteinBinding	70% (en)
foaf:page	http://www.drugs.com/cdi/pentoxifylline.html http://www.rxlist.com/cgi/generic/pentox.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4001-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4007-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4006-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4003-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4004-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4005-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B3FFF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4017-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B3FFD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4000-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4019-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B3FFE-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Pentoxifylline
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B400D-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B400E-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B4008-363D-11E5-9242-09173F13E4C5

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