| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. Haloprogin is no longer available in the United States and has been discontinued. (en)
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| http://linked.open...generalReferences
| - # Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5422306 # Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4608935 (en)
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| http://linked.open...gy/drugbank/group
| - approved (en)
- withdrawn (en)
|
| http://linked.open...ugbank/indication
| - Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor. (en)
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| http://linked.open...bank/manufacturer
| |
| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Haloprogin (en)
- Halotex (en)
- Haloprogina (en)
- Haloprogine (en)
- Haloproginum (en)
|
| http://linked.open...ynthesisReference
| - U.S. Patent 3,322,813. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
| |
| http://linked.open.../affectedOrganism
| - Dermatophytic fungi including Trichophyton, Microsporum and Epidermophyton (en)
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| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
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| http://linked.open...gbank/containedIn
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| http://linked.open...k/Bioavailability
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| http://linked.open...bank/Ghose-Filter
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| http://linked.open...nk/MDDR-Like-Rule
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| http://linked.open...ank/Melting-Point
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| http://linked.open...k/Number-of-Rings
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| http://linked.open...siological-Charge
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| http://linked.open...bank/Rule-of-Five
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| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...-strongest-basic-
| |
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