About: Polymyxin B Sulfate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18447592 # Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17878146 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of <i>Pseudomonas aeruginosa</i>. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Polymyxin B Sulfate (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • The drug is excreted slowly by the kidneys. (en)
http://linked.open.../drugbank/synonym
  • Polimixina B (en)
  • Polymyxin B (en)
  • Polymyxin-B-Sulfat (en)
  • Polymyxine B (en)
  • Polymyxine B (sulfate de) (en)
  • Polymyxini B sulfas (en)
  • Polymyxinum B (en)
http://linked.open...drugbank/toxicity
  • Overdose can cause stomach pains, vomiting, and diarrhea. (en)
http://linked.open.../drugbank/mixture
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 91 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software