About: Malathion

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Malathion is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. Malathion is an irreversible cholinesterase inhibitor and has low human toxicity. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5DBC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5DBD-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Baker EL Jr, Warren M, Zack M, Dobbin RD, Miles JW, Miller S, Alderman L, Teeters WR: Epidemic malathion poisoning in Pakistan malaria workers. Lancet. 1978 Jan 7;1(8054):31-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/74508 # Bonner MR, Coble J, Blair A, Beane Freeman LE, Hoppin JA, Sandler DP, Alavanja MC: Malathion exposure and the incidence of cancer in the agricultural health study. Am J Epidemiol. 2007 Nov 1;166(9):1023-34. Epub 2007 Aug 23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17720683 # Edwards JW, Lee SG, Heath LM, Pisaniello DL: Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environ Res. 2007 Jan;103(1):38-45. Epub 2006 Aug 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16914134 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	8-24 hours (en)
http://linked.open...ugbank/indication	For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair. (en)
http://linked.open...bank/manufacturer	A-S Medication Solutions LLC Atlantic Biologicals Corporation
sameAs	Malathion
Title	Malathion (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/bindingdb/50240924 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/chebi/6651 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/chemspider/3864 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/drugbank/DB00772 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/kegg-compound/C07497 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/kegg-drug/D00534 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/national-drug-code-directory/68882-014-60 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/pubchem-compound/4004 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/pubchem-substance/46505287 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/pharmgkb/PA164748092 http://linked.opendata.cz/resource/drugbank/drug/DB00772/identifier/wikipedia/Malathion
http://linked.open...mechanismOfAction	Malathion is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malathion is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death. (en)
http://linked.open...drugbank/packager	Amerisource Health Services Corp. Amkas Laboratories Inc. Amneal Pharmaceuticals Apotex Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/7560445
http://linked.open.../drugbank/synonym	Malathion (en) Karbofos (en) Carbophos (en) Maldison (en) Mercaptothion (en) O,O-Dimethyldithiophosphate diethylmercaptosuccinate (en) Diethyl (dimethoxyphosphinothioylthio)succinate (en) O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) (en) O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl (en) O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate (en) [(Dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester (en) O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate (en)
http://linked.open...drugbank/toxicity	Malathion is slightly toxic via the oral route, with reported oral LD<sub>50</sub> values of 1000 mg/kg to greater than 10,000 mg/kg in the rat. It is also slightly toxic via the dermal route, with reported dermal LD<sub>50</sub> values of greater than 4000 mg/kg in rats. Moderate poisoning can result in chest tightness, difficulty breathing, bradycardia, tachycardia, tremor/ataxia, blurred vision, and confusion. Severe, life-threatening signs include coma, seizures, respiratory arrest, and paralysis. Malathion may also be irritating to the skin and eyes. (en)
http://linked.open...ynthesisReference	Noel Rouy, Georges Gros, "Process for the preparation of malathion." U.S. Patent US4367180, issued August, 1969. (en)
foaf:page	http://www.drugs.com/cdi/malathion.html http://www.rxlist.com/cgi/generic3/ovide.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5DC2-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5DC8-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5DC7-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5DC4-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5DC5-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5DC6-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5DC0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5DD7-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5DBE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5DC1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5DDA-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5DBF-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Malathion
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5DCE-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5DCF-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5DC9-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5DCA-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5DCC-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5DCB-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5DCD-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Malathion in an acetone vehicle has been reported to be absorbed through normal human skin only to the extent of 8% of the applied dose. Absorption may be increased when malathion is applied to damaged skin. Malathion is rapidly and effectively absorbed by practically all routes including the gastrointestinal tract, skin, mucous membranes, and lungs. However, it is readily excreted in the urine, and does not accumulate in organs or tissues. (en)
http://linked.open.../affectedOrganism	Head lice (en)
http://linked.open...casRegistryNumber	121-75-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Malathion 0.5% lotion Ovide 0.5% lotion Ovide 0.5% Lotion 59ml Bottle
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5DD3-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Boiling-Point	http://linked.opendata.cz/resource/drugbank/property/271B5DD9-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B5DD5-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B5DD6-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B5DD8-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B5DD2-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5DD1-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5DD4-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5DC3-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5DD0-363D-11E5-9242-09173F13E4C5

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