| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. [PubChem] (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Methimazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Methimazole is excreted in the urine. (en)
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| http://linked.open.../drugbank/synonym
| - Thiamazole (en)
- Methimazole (en)
- Danantizol (en)
- Favistan (en)
- Strumazol (en)
- Tapazole (en)
- Thacapzol (en)
- Mercazolyl (en)
- Thiamazol (en)
- Tiamazol (en)
- 1-METHYL-1,3-dihydro-2H-imidazole-2-thione (en)
- 1-Methylimidazole-2(3H)-thione (en)
- Thiamazolum (en)
- USAF el-30 (en)
|
| http://linked.open...drugbank/toxicity
| - Oral LD<sub>50</sub> in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression. (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Always take at the same moment in regard to meals, food may affect absorption unpredictably. (en)
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| http://linked.open.../drugbank/mixture
| |
| http://linked.open...nk/proteinBinding
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open...ugbank/absorption
| - Rapid with an oral bioavailability of 93%. (en)
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| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
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