About: Tetracycline

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B59F7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59F8-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# "Link":http://en.wikipedia.org/wiki/Tetracycline # Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. Epub 2010 Jun 30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20592239 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	6-12 hours (en)
http://linked.open...ugbank/indication	Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin. (en)
http://linked.open...bank/manufacturer	Heritage pharmaceuticals inc Bristol laboratories inc div bristol myers co Murfreesboro Pharmaceutical Nursing Supply Nexgen Pharma Inc. Novartis AG Nucare Pharmaceuticals Inc. Apothecon inc div bristol myers squibb Angus chemical co Patient First Corp. On site therapeutics inc PD-Rx Pharmaceuticals Inc. Lederle laboratories div american cyanamid co Pharmaceutical Utilization Management Program VA Inc. Physicians Total Care Inc. Par pharmaceutical Ivax pharmaceuticals inc sub teva pharmaceuticals usa A-S Medication Solutions LLC
sameAs	Tetracycline
Title	Tetracycline (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/chebi/27902 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/chemspider/4510286 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/drugbank/DB00759 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/kegg-compound/C06570 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/kegg-drug/D00201 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/national-drug-code-directory/0172-2416-60 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/pdb/ATC http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/pharmgkb/PA451640 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/pubchem-compound/5280962 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/pubchem-substance/46506693 http://linked.opendata.cz/resource/drugbank/drug/DB00759/identifier/wikipedia/Tetracycline
http://linked.open...mechanismOfAction	Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. (en)
http://linked.open...drugbank/packager	Bedford Labs Ben Venue Laboratories Inc. Bioniche Pharma Blansett Pharmacal Co. Inc. Blenheim Pharmacal Allerquest LLC Bristol-Myers Squibb Co. Bryant Ranch Prepack Allerquest llc Pharmaceutical Utilization Management Program VA Inc. Comprehensive Consultant Services Inc. Concord Labs Corepharma LLC CVS Pharmacy D.M. Graham Laboratories Inc. Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. Everett Laboratories Inc. Forest Pharmaceuticals G & W Labs Gilbert Laboratories GlaxoSmithKline Inc. Goldline Laboratories Inc. Alcon Laboratories Alcon laboratories inc Hospira Inc. Innoviant Pharmacy Inc. J T Baker Kaiser Foundation Hospital Keene Pharmaceuticals Inc. Keltman Pharmaceuticals Inc. Lannett Co. Inc. Liberty Pharmaceuticals Luitpold Pharmaceuticals Inc. Lunsco Inc. Major Pharmaceuticals Mallinckrodt Inc. Marlex Pharmaceuticals Marnel Pharmaceuticals Inc. Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Apotheca Inc. A-S Medication Solutions LLC Axcan Pharma Inc. Barr Pharmaceuticals Belgomex Sprl Actavis Group Aidarex Pharmacuticals LLC Alphagen Laboratories Inc. American Regent Amerisource Health Services Corp. Amneal Pharmaceuticals Apotheca Inc. APP Pharmaceuticals A-S Medication Solutions LLC Athlon Pharmaceuticals Inc. Atley Pharmaceuticals
http://linked.open...outeOfElimination	They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form. (en)
http://linked.open.../drugbank/synonym	Abramycin (en) Achromycin (en)

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