About: Nitroglycerin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5038-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5039-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B503F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5040-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5041-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5042-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5043-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5044-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5045-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5046-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5047-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5048-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5049-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B504F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5050-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5051-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5052-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5053-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5054-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5055-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5056-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5057-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5058-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5059-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B505A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5036-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5037-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	3 minutes (en)
http://linked.open...ugbank/indication	For the prevention of angina (en)
http://linked.open...bank/manufacturer	Prepak Systems Inc. Novartis pharmaceuticals corp Rebel Distributors Corp. Redpharm Drug Abraxis pharmaceutical products Hospira inc Sandoz Luitpold pharmaceuticals inc Bristol-Myers Squibb Co. Baxter healthcare corp Bristol myers squibb Alcon laboratories inc Allergan pharmaceutical Pfizer pharmaceuticals ltd Pharmaceutical Utilization Management Program VA Inc. L perrigo co Graceway pharmaceuticals llc Physicians Total Care Inc. Pliva Inc. Monarch pharmaceuticals inc
sameAs	Nitroglycerin
Title	Nitroglycerin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/chebi/28787 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/chemspider/4354 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/drugbank/DB00727 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/kegg-compound/C07455 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/kegg-drug/D00515 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/national-drug-code-directory/0168-0326-08 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/pharmgkb/PA450644 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/pubchem-compound/4510 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/pubchem-substance/46509120 http://linked.opendata.cz/resource/drugbank/drug/DB00727/identifier/wikipedia/Nitroglycerin
http://linked.open...mechanismOfAction	Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation. (en)
http://linked.open...drugbank/packager	3M Health Care MWI Veterinary Supply Co. American Regent A-S Medication Solutions LLC Baxter International Inc. Bradley Pharmaceuticals Inc. Bristol-Myers Squibb Co. C.O. Truxton Inc. Cardinal Health Pfizer Inc. Amerisource Health Services Corp. Barr Pharmaceuticals 4uOrtho LLC Actavis Group Advanced Pharmaceutical Services Inc. A-S Medication Solutions LLC Aidarex Pharmacuticals LLC Akorn Inc. Alcon Laboratories Dispensing Solutions Sandoz H and H Laboratories Amerisource Health Services Corp. Pharmaceutical Utilization Management Program VA Inc.

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