About: Azatadine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. (en)
http://linked.open...generalReferences	# Zhang D, Hansen EB Jr, Deck J, Heinze TM, Sutherland JB, Cerniglia CE: Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Appl Environ Microbiol. 1996 Sep;62(9):3477-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8795241 # Katelaris C: Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1982614 # Small P, Barrett D, Biskin N: Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation. Ann Allergy. 1990 Feb;64(2 Pt 1):129-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1968324 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the relief of the symptoms of upper respiratory mucosal congestion in perennial and allergic rhinitis, and for the relief of nasal congestion and eustachian t.b. congestion. (en)
http://linked.open...bank/manufacturer	Coupler Enterprises Inc.
sameAs	Azatadine
Title	Azatadine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/bindingdb/22868 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/chebi/2946 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/chemspider/18709 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/drugbank/DB00719 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/kegg-compound/C07774 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/pubchem-compound/19861 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/pubchem-substance/46507958 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/pharmgkb/PA164747157 http://linked.opendata.cz/resource/drugbank/drug/DB00719/identifier/wikipedia/Azatadine
http://linked.open...mechanismOfAction	Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. (en)
http://linked.open.../drugbank/synonym	Azatadine (en) Azatadine Maleate (en) 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine (en) Azatadin (en) Azatadina (en) Azatadinum (en) 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (en)
http://linked.open...drugbank/toxicity	The oral LD<sub>50</sub> in mature rats and mice was greater than 1700 mg/kg and 600 mg/kg, respectively. Symptoms of overdose include clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/04-04-92
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Take with food to reduce irritation. (en)
http://linked.open.../drugbank/mixture	Cedrin Trinalin Repetabs
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Raymond E. Dagger, Linda A. Motyka, "Process for preparing intermediates for azatidine." U.S. Patent US4954632, issued September 04, 1990. (en)
foaf:page	http://www.drugs.com/mtm/azatadine.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tri1460.shtml http://www.rxlist.com/cgi/generic3/azatpseud.htm
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http://linked.open...l/drug/hasATCCode	Azatadine
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http://linked.open...ugbank/absorption	Well absorbed after oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	3964-81-6 (en)
http://linked.open...drugbank/category	(en)
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