About: Chlorpropamide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. Renal and hepatic dysfunction may increase the risk of hypoglycemia. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4126-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4127-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Approximately 36 hours with interindividual variation ranging from 25-60 hours. Duration of effect persists for at least 24 hours. (en)
http://linked.open...ugbank/indication	For treatment of NIDDM in conjunction with diet and exercise. (en)
http://linked.open...bank/manufacturer	A-S Medication Solutions LLC Sandoz Amend Amneal Pharmaceuticals Apotheca Inc. Barr Pharmaceuticals Amerisource Health Services Corp. Aurobindo Pharma Ltd. Ben Venue Laboratories Inc. Cadila Healthcare Ltd. Consolidated Midland Corp. Dept Health Central Pharmacy Direct Dispensing Inc. Dispensing Solutions
sameAs	Chlorpropamide
Title	Chlorpropamide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/chebi/3650 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/chemspider/2626 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/drugbank/DB00672 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/kegg-drug/D00271 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/national-drug-code-directory/0378-0197-01 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/pharmgkb/PA448966 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/pubchem-compound/2727 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/pubchem-substance/46506402 http://linked.opendata.cz/resource/drugbank/drug/DB00672/identifier/wikipedia/Chlorpropamide
http://linked.open...mechanismOfAction	Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. (en)
http://linked.open...drugbank/packager	Central Texas Community Health Centers Direct Dispensing Inc. Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. Major Pharmaceuticals Murfreesboro Pharmaceutical Nursing Supply Mylan Nucare Pharmaceuticals Inc. PCA LLC PD-Rx Pharmaceuticals Inc. Pfizer Inc. Pharmedix Physicians Total Care Inc. Pliva Inc. Prepackage Specialists AAIPharma Inc. Marathon Pharmaceuticals Ranbaxy Laboratories Advanced Pharmaceutical Services Inc.
http://linked.open...outeOfElimination	80-90% of a single oral dose is excreted in the urine as unchaged drug and metabolites within 96 hours. (en)
http://linked.open.../drugbank/synonym	Chlorpropamide (en) Chlorpropamid (en) 1-(P-Chlorobenzenesulfonyl)-3-propylurea (en) 1-(P-Chlorophenylsulfonyl)-3-propylurea (en) 1-Propyl-3-(P-chlorobenzenesulfonyl)urea (en) Chlorpropamidum (en) Clorpropamida (en) N-(4-Chlorophenylsulfonyl)-n'-propylurea (en) N-(P-Chlorobenzenesulfonyl)-n'-propylurea (en) N-Propyl-n'-(P-chlorobenzenesulfonyl)urea (en) N-Propyl-n'-P-chlorophenylsulfonylcarbamide (en) 4-chloro-N-((Propylamino)carbonyl)benzenesulfonamide (en) 4-chloro-N-[(Propylamino)carbonyl]benzenesulfonamide (en)
http://linked.open...drugbank/toxicity	IPN-RAT LD<sub>50</sub> 580 mg/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-20-20
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Food reduces the rate of absorption. (en) Take 30 minutes before meal. (en)
http://linked.open.../drugbank/mixture	Bidiabe Chlorformin Fenclor Insogen Plus Obinese Pleiamide
http://linked.open...nk/proteinBinding	Highly bound to plasma proteins. (en)
http://linked.open...ynthesisReference	McLamore, W.M.; U S . Patent 3,349,124; October 24,1967; assigned to Chas. Pfizer Co., Inc. (en)
foaf:page	http://www.drugs.com/cdi/chlorpropamide.html http://www.rxlist.com/cgi/generic2/chlorpro.htm
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http://linked.open...l/drug/hasATCCode	Chlorpropamide
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