About: Histamine Phosphate

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3EE2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EE3-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function. (en)
http://linked.open...bank/manufacturer	C.O. Truxton Inc.
sameAs	Histamine Phosphate
Title	Histamine Phosphate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/chemspider/58959 http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/drugbank/DB00667 http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/national-drug-code-directory/0268-0248-05 http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/pubchem-compound/65513 http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/pubchem-substance/46509118 http://linked.opendata.cz/resource/drugbank/drug/DB00667/identifier/pharmgkb/PA449880
http://linked.open...mechanismOfAction	Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Histamine has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Histamine also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively. (en)
http://linked.open...drugbank/packager	ALK-Abello Inc. Baxter International Inc. Medisca Inc. Bryant Ranch Prepack
http://linked.open.../drugbank/synonym	Histamine biphosphate (en) Histamine dihydrogen phosphate (en) Histamine diphosphate (en) 4-(2-Aminoethyl)imidazole di-acid phosphate (en) Histamine acid phosphate (en) Histamine phosphate (1:2) (en) Histaminum (en) 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate) (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/36-36-00 http://linked.opendata.cz/resource/AHFS/36-89-00%2A
foaf:page	http://www.drugs.com/cons/histamine-phosphate-intradermal.html
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B3EE5-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B3EEB-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3EEA-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3EE7-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3EE8-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B3EE9-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B3EE4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3EFC-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Histamine phosphate
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EF1-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EF2-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B3EEC-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B3EED-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B3EEF-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B3EEE-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B3EF0-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Readily absorbed after parenteral administration (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	51-74-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Eligard 45 mg syringe Histatrol 1:10000 vial Histamine phosphate 100% cryst
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B3EF7-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B3EF9-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B3EFA-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EFB-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B3EF6-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B3EF5-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B3EF8-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B3EE6-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B3EF3-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B3EF4-363D-11E5-9242-09173F13E4C5

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