| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A theophylline derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| - 2 hours (range 1.8 - 2.1 hours) (en)
|
| http://linked.open...ugbank/indication
| - For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Dyphylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged. (en)
|
| http://linked.open.../drugbank/synonym
| - Diprophylline (en)
- Dyphylline (en)
- (+-)-7-(2,3-Dihydroxypropyl)theophylline (en)
- (+-)-Diprophylline (en)
- (+-)-Dyphylline (en)
- (1,2-Dihydroxy-3-propyl)thiophyllin (en)
- (±)-diprophylline (en)
- (±)-dyphylline (en)
- 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine (en)
- 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine (en)
- 7-(2,3-Dihydroxypropyl)theophylline (en)
- 7-(beta,gamma-Dihydroxypropyl)theophylline (en)
- 7-(β,γ-dihydroxypropyl)theophylline (en)
- Dihydroxypropyl theopylin (en)
- Diprofilina (en)
- Diprophyllinum (en)
- 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (en)
|
| http://linked.open...drugbank/toxicity
| - LD<sub>50</sub>=1954 mg/kg (orally in mice) (en)
|
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ynthesisReference
| - Jones, J.W. and Maney, P.V.; U.S. Patent 2,575,344; November 20,1951; assigned to the State of Iowa. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...strongest-acidic-
| |
| http://linked.open...-strongest-basic-
| |
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