About: Gonadorelin

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About: Gonadorelin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. (en)
http://linked.open...generalReferences	# Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16373418 # Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16621281 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes (en)
http://linked.open...ugbank/indication	For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation. (en)
http://linked.open...bank/manufacturer	Ferring pharmaceuticals inc Baxter healthcare corp anesthesia critical care
sameAs	Gonadorelin
Title	Gonadorelin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/chemspider/33562 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/drugbank/DB00644 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/kegg-compound/C07607 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/pharmgkb/PA449801 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/pubchem-compound/36523 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/pubchem-substance/46506144 http://linked.opendata.cz/resource/drugbank/drug/DB00644/identifier/wikipedia/Gonadorelin
http://linked.open...mechanismOfAction	Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids. (en)
http://linked.open...drugbank/packager	Hospira Inc. Intervet International
http://linked.open.../drugbank/synonym	Gonadorelin (en) Fertagyl (en) GnRH (en) GnRH-I (en) Gonadoliberin I (en) Gonadorelina (en) Gonadorelinum (en) Gonadoréline (en) Luteinizing Hormone-releasing Factor Diacetate Tetrahydrate (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>>3000 mg/kg (rat, oral) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-18-00
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Rainer Uhmann, Kurt Radscheit, "Process for the low-racemization preparation of peptide intermediates of the synthesis of gonadorelin and gonadorelin analogs, and new intermediates for this process." U.S. Patent US4691008, issued December, 1984. (en)
foaf:page	http://www.drugs.com/cdi/gonadorelin.html http://www.rxlist.com/cgi/generic2/gonadorelin.htm
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http://linked.open...l/drug/hasATCCode	Gonadorelin Gonadorelin
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http://linked.open...ugbank/absorption	Rapidly absorbed when injected (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	6918-09-8 (en)
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