About: Clofibrate

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About: Clofibrate Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Half-life in normal volunteers averages 18 to 22 hours (range 14 to 35 hours) but can vary by up to 7 hours in the same subject at different times. (en)
http://linked.open...ugbank/indication	For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet. This helps control high cholesterol and high triglyceride levels. (en)
http://linked.open...bank/manufacturer	Professional Co. Banner pharmacaps inc Actavis Group Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Amerisource Health Services Corp.
sameAs	Clofibrate
Title	Clofibrate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/chebi/3750 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/chemspider/2694 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/drugbank/DB00636 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/kegg-compound/C06916 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/kegg-drug/D00279 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/pharmgkb/PA449045 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/pubchem-compound/2796 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/pubchem-substance/46504748 http://linked.opendata.cz/resource/drugbank/drug/DB00636/identifier/wikipedia/Clofibrate
http://linked.open...mechanismOfAction	Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Clofibrate also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. Also, as a fibrate, Clofibrate is an agonist of the PPAR-α receptor[4] in muscle, liver, and other tissues. This agonism ultimately leads to modification in gene expression resulting in increased beta-oxidation, decreased triglyceride secretion, increased HDL, increased lipoprotein lipase activity. (en)
http://linked.open...drugbank/packager	Banner Pharmacaps Inc. Major Pharmaceuticals Novopharm Ltd.
http://linked.open.../drugbank/synonym	Clofibrate (en) Atromid-S (en) ELPI (en) Lipofacton (en) Liprin (en) Clofibrato (en) Clofibratum (en) EPIB (en) Ethyl chlorophenoxyisobutyrate (en) Ethyl clofibrate (en) Ethyl 2-(P-chlorophenoxy)isobutyrate (en) alpha-p-Chlorophenoxyisobutyryl ethyl ester (en) 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester (en) 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester (en) alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester (en)
http://linked.open...drugbank/toxicity	Oral, mouse: LD<sub>50</sub> = 1220 mg/kg; Oral, rabbit: LD<sub>50</sub> = 1370 mg/kg; Oral, rat: LD<sub>50</sub> = 940 mg/kg. No reported case of overdosage in humans. (en)
http://linked.open...k/foodInteraction	Take with food, since it may reduce gastric irritation. (en)
http://linked.open...nk/proteinBinding	Highly protein-bound (95% to 97%). (en)
http://linked.open...ynthesisReference	Jones, W.G.M.,Thorp, J.M. and Waring, W.S.; U.S. Patent 3,262,850; July 26, 1966; assigned to Imperial Chemical Industries Limited, England. (en)
foaf:page	http://www.drugs.com/mtm/clofibrate.html http://www.rxlist.com/cgi/generic2/clofibrate.htm
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5DBE-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5DBD-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5DBA-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5DBB-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Clofibrate
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5DC4-363D-11E5-9242-09173F13E4C5
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http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5DBF-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5DC0-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5DC2-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5DC1-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5DC3-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	637-07-0 (en)
http://linked.open...drugbank/category	(en)
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5DC7-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5DCA-363D-11E5-9242-09173F13E4C5
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5DC6-363D-11E5-9242-09173F13E4C5

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