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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...ugbank/indication
  • For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters). (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Docosanol (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Docosanol works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Unlike other cold-sore antivirals, docosanol does not act directly on the virus, and as such it is unlikely it will produce drug resistant mutants of HSV. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Docosanol (en)
  • Abreva (en)
  • Behenyl alcohol (en)
  • 1-Docosanol (en)
  • Behenic alcohol (en)
  • Docosan-1-ol (en)
  • Docosyl alcohol (en)
  • N-Docosanol (en)
  • Tadenan (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia. (en)
http://linked.open.../drug/hasAHFSCode
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
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http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
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http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Topical absorption has been shown to be minimal under conditions reflecting normal clinical use. (en)
http://linked.open.../affectedOrganism
  • Herpes simplex virus (en)
http://linked.open...casRegistryNumber
  • 30303-65-2 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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