About: Rifabutin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B56C5-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	45 (± 17) hours (en)
http://linked.open...ugbank/indication	For the prevention of disseminated <i>Mycobacterium avium</i> complex (MAC) disease in patients with advanced HIV infection. (en)
http://linked.open...bank/manufacturer	Sandoz
sameAs	Rifabutin
Title	Rifabutin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/chebi/8857 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/chemspider/4883445 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/drugbank/DB00615 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/kegg-compound/C07235 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/kegg-drug/D00424 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/national-drug-code-directory/0013-5301-17 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/pdb/RBT http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/pharmgkb/PA451249 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/pubchem-compound/6323490 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/pubchem-substance/46506468 http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/wikipedia/Rifabutin
http://linked.open...mechanismOfAction	Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death. (en)
http://linked.open...drugbank/packager	Provident Pharmaceuticals LLC Amerisource Health Services Corp. Pfizer Inc. Gate Pharmaceuticals Medisca Inc.
http://linked.open...outeOfElimination	A mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces. (en)
http://linked.open.../drugbank/synonym	Rifabutin (en) Ansamycin (en) Rifabutine (en) 4-N-Isobutylspiropiperidylrifamycin S (en) Ansamicin (en) Mycobutin (tn) (en) Rifabutina (en) Rifabutinum (en) 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S (en) 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub> = 4.8 g/kg (mouse, male) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-16-04
http://linked.open...k/foodInteraction	High-fat meals slow the rate of absorption. (en) Take with food to reduce irritation. (en)
http://linked.open...nk/proteinBinding	85% (en)
foaf:page	http://www.drugs.com/cdi/rifabutin.html http://www.rxlist.com/cgi/generic2/rifabutin.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B56CA-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B56D0-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B56CF-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B56CC-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B56CD-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B56CE-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B56C8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B56E0-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B56C6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B56C9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B56E1-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B56C7-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Rifabutin
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B56D6-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B56D7-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B56D1-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B56D2-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B56D4-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B56D3-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B56D5-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%. (en)
http://linked.open.../affectedOrganism	Enteric bacteria and other eubacteria (en) Mycobacterium tuberculosis (en) Mycobacterium avium (en) Mycobacterium leprae (en)
http://linked.open...casRegistryNumber	72559-06-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 0.69 +/- 0.32 L/hr/kg (en)
http://linked.open...gbank/containedIn	Biaxin 250 mg tablet
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B56DC-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B56DE-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B56DF-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B56DB-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B56DA-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B56DD-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B56CB-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B56D8-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B56D9-363D-11E5-9242-09173F13E4C5

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