About: Fenfluramine

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About: Fenfluramine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis. (en)
http://linked.open...generalReferences	# Roth BL: Drugs and valvular heart disease. N Engl J Med. 2007 Jan 4;356(1):6-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17202450 (en)
http://linked.open...gy/drugbank/group	illicit (en) withdrawn (en)
http://linked.open...drugbank/halfLife	20 hours (en)
http://linked.open...ugbank/indication	For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. (en)
sameAs	Fenfluramine
Title	Fenfluramine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/chebi/5000 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/chemspider/3220 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/drugbank/DB00574 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/kegg-compound/C06996 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/pharmgkb/PA449592 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/pubchem-compound/3337 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/pubchem-substance/46506096 http://linked.opendata.cz/resource/drugbank/drug/DB00574/identifier/wikipedia/Fenfluramine
http://linked.open...mechanismOfAction	Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. (en)
http://linked.open.../drugbank/synonym	Fenfluramina (en) Fenfluraminum (en)
http://linked.open...drugbank/toxicity	Agitation and drowsiness, confusion, flushing, tremor (or shivering), fever, sweating, abdominal pain, hyperventilation, and dilated non-reactive pupils seem frequent in fenfluramine overdosage. Reflexes may be either exaggerated or depressed and some patients may have rotary nystagmus. Tachycardia may be present, but blood pressure may be normal or only slightly elevated. Convulsions, coma, and ventricular extrasystoles, culminating in ventricular fibrillation, and cardiac arrest, may occur at higher dosages. Less than 5 mg/kg are toxic to humans. Five-ten mg/kg may produce coma and convulsions. Reported single overdoses have ranged from 300 to 2000 mg; the lowest reported fatal dose was a few hundred mg in a small child, and the highest reported nonfatal dose was 1800 mg in an adult. Most deaths were apparently due to respiratory failure and cardiac arrest. Toxic effects will appear within 30 to 60 minutes and may progress rapidly to potentially fatal complications in 90 to 240 minutes. Symptoms may persist for extended periods depending upon the dose ingested. (en)
http://linked.open...k/foodInteraction	Take without regard to meals. (en)
http://linked.open.../drugbank/mixture	Fen-phen
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Vincenzo Cannata, Barbara Galbiati, Angelo Spreafico, "Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine." U.S. Patent US5811586, issued August, 1965. (en)
foaf:page	http://www.rxlist.com/cgi/generic/fenflur.htm
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http://linked.open...ugbank/absorption	Fenfluramine is well-absorbed from the gastrointestinal tract, and a maximal anorectic effect is generally seen after 2 to 4 hours. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	458-24-2 (en)
http://linked.open...drugbank/category	(en)
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