| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| - 3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males. (en)
|
| http://linked.open...ugbank/indication
| - For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine. (en)
|
| http://linked.open.../drugbank/synonym
| - Atropine (en)
- Atropin (en)
- Tropine tropate (en)
- (+,-)-Tropyl tropate (en)
- (+-)-Atropine (en)
- (+-)-Hyoscyamine (en)
- (±)-atropine (en)
- (±)-hyoscyamine (en)
- 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate (en)
- Atropina (en)
- Atropinum (en)
- Mydriasine (en)
- dl-Hyoscyamine (en)
- dl-tropyltropate (en)
- (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate (en)
- [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate (en)
- 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate (en)
|
| http://linked.open...drugbank/toxicity
| - Oral, mouse: LD<sub>50</sub> = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur. (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take with food. (en)
|
| http://linked.open.../drugbank/mixture
| |
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