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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 1 hour (en)
http://linked.open...ugbank/indication
  • For the treatment of respiratory tract infections caused by <i>Streptococcus pneumoniae</i> and <i>Streptococcus pyogenes</i>; otitis media due to <i>Streptococcus pneumoniae</i>, <i>Haemophilus influenzae</i>, <i>Staphylococcus aureus</i>, <i>Streptococcus pyogenes</i>, and <i>Moraxella catarrhalis</i>; skin and skin structure infections caused by <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i>; bone infections caused by <i>Staphylococcus aureus</i> and/or <i>Proteus mirabilis</i>; genitourinary tract infections, including acute prostatitis, caused by <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, and <i>Klebsiella pneumoniae</i>. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Cephalexin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor. (en)
http://linked.open...drugbank/packager
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