About: Carbamazepine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of phenytoin; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B490D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B490E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B490F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4910-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4911-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4912-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4913-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4914-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4915-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4916-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4917-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4918-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Staines AG, Coughtrie MW, Burchell B: N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7. J Pharmacol Exp Ther. 2004 Dec;311(3):1131-7. Epub 2004 Aug 3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15292462 # Sisodiya SM, Goldstein DB: Drug resistance in epilepsy: more twists in the tale. Epilepsia. 2007 Dec;48(12):2369-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18088268 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	Initial half-life values range from 25-65 hours, decreasing to 12-17 hours on repeated doses. (en)
http://linked.open...ugbank/indication	For the treatment of epilepsy and pain associated with true trigeminal neuralgia. (en)
http://linked.open...bank/manufacturer	Shire development inc Validus pharmaceuticals inc Taro pharmaceutical industries ltd Wockhardt eu operations (swiss) ag Novartis pharmaceuticals corp Taro pharmaceuticals usa inc Cadista pharmaceuticals inc Heritage Pharmaceuticals Kaiser Foundation Hospital Actavis elizabeth llc Apotex inc etobicoke site Inwood laboratories inc sub forest laboratories inc Pliva inc Usl pharma inc Warner chilcott div warner lambert co
sameAs	Carbamazepine
Title	Carbamazepine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/chebi/3387 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/chemspider/2457 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/drugbank/DB00564 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/kegg-compound/C06868 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/kegg-drug/D00252 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/national-drug-code-directory/0228-2143-10 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/pubchem-compound/2554 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/pubchem-substance/46507583 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/pharmgkb/PA448785 http://linked.opendata.cz/resource/drugbank/drug/DB00564/identifier/wikipedia/Carbamazepine
http://linked.open...mechanismOfAction	Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties. (en)
http://linked.open...drugbank/packager	Alvogen inc Key Co. Mason Distributors Medtrition Inc. Nestle Nutrition Qualitest Nutritional restart pharmaceutical lp Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Amend Apotex Inc. A-S Medication Solutions LLC Caraco Pharmaceutical Labs Cardinal Health Redpharm Drug Coupler Enterprises Inc. Direct Dispensing Inc. Dispensing Solutions Clonmel healthcare ltd DSM Corp. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Hawkins Inc. Heartland Repack Services LLC Innoviant Pharmacy Inc. Inwood Labs Acs dobfar info sa Lake Erie Medical and Surgical Supply Baxter International Inc. Liberty Pharmaceuticals Medisca Inc. Murfreesboro Pharmaceutical Nursing Supply Sandoz C.O. Truxton Inc. Elkins sinn div ah robins co inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Apothecon sub bristol myers squibb co Apothecon inc div bristol myers squibb Remedy Repack Resource Optimization and Innovation LLC Barr Pharmaceuticals Sandoz F Hoffmann-La Roche Ltd. Mylan Pharmaceutical Utilization Management Program VA Inc. Physicians Total Care Inc. Ranbaxy Laboratories Torpharm Inc. Torrent Pharmaceuticals Tya Pharmaceuticals UDL Laboratories Validus Pharmaceuticals Vangard Labs Inc. Vistapharm Inc.

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