About: Zanamivir

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A guanido-neuraminic acid that is used to inhibit neuraminidase. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4767-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4768-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Meindl P, Bodo G, Palese P, Schulman J, Tuppy H: Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. Virology. 1974 Apr;58(2):457-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4362431 # von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW, et al.: Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature. 1993 Jun 3;363(6428):418-23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8502295 # Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T: Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases. Antimicrob Agents Chemother. 2008 Aug 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18694948 # Sugaya N, Tamura D, Yamazaki M, Ichikawa M, Kawakami C, Kawaoka Y, Mitamura K: Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children. Clin Infect Dis. 2008 Aug 1;47(3):339-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18582202 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	2.5-5.1 hours (en)
http://linked.open...ugbank/indication	For the prevention and treatment of influenza A and B. (en)
http://linked.open...bank/manufacturer	Amerisource Health Services Corp.
sameAs	Zanamivir
Title	Zanamivir (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/bindingdb/4934 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/chebi/50663 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/chemspider/54842 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/drugbank/DB00558 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/kegg-compound/C08095 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/kegg-drug/D00902 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/national-drug-code-directory/0173-0681-01 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/pdb/ZMR http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/pubchem-compound/60855 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/pubchem-substance/46508581 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/pharmgkb/PA164740891 http://linked.opendata.cz/resource/drugbank/drug/DB00558/identifier/wikipedia/Zanamivir
http://linked.open...mechanismOfAction	The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others. (en)
http://linked.open...drugbank/packager	Aidarex Pharmacuticals LLC Dispensing Solutions GlaxoSmithKline Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2081356 http://linked.opendata.cz/resource/drugbank/patent/2291994 http://linked.opendata.cz/resource/drugbank/patent/5360817 http://linked.opendata.cz/resource/drugbank/patent/6294572
http://linked.open...outeOfElimination	It is excreted unchanged in the urine with excretion of a single dose completed within 24 hours. Unabsorbed drug is excreted in the feces.Zanamivir is renally excreted as unchanged drug. (en)
http://linked.open.../drugbank/synonym	ZANAMIVIR (en) Relenza (en) GANA (en) GNA (en) Modified sialic acid (en) ZMR (en) Zanamavir (en) 5-acetamido-2,6-Anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid (en) 4-Guanidino-neu5ac2en (en) 5-(acetylamino)-2,6-Anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid (en) (2R,3R,4S)-3-(acetylamino)-4-Carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid (en) 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-18-28
http://linked.open...nk/proteinBinding	Zanamivir has limited plasma protein binding (<10%). (en)
http://linked.open...ynthesisReference	Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Ashwini Amol Sawant, Sanoj Thoppil, "Process for Preparing Zanamivir and Intermediates for Use in the Process." U.S. Patent US20110257418, issued October 20, 2011. (en)
foaf:page	http://www.drugs.com/cdi/zanamivir.html http://www.rxlist.com/cgi/generic2/zanam.htm
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http://linked.open...l/drug/hasATCCode	Zanamivir
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http://linked.open...ugbank/absorption	Absolute bioavailability is very low following oral administration (2%). Following oral inhalation, bioavailability is 4% to 17%. (en)
http://linked.open.../affectedOrganism	Influenza A virus (en) Influenza B virus (en)
http://linked.open...casRegistryNumber	139110-80-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 2.5 - 10.9 L/h [Following oral inhalation 10 mg] * 5.3 L/h [Normal renal function receiving IV single dose of 4 mg or 2 mg] * 2.7 L/h [Patients with mild and moderate renal impairement receiving IV single dose of 4 mg or 2 mg] * 0.8 L/h [Patients with severe renal impairement receiving IV single dose of 4 mg or 2 mg] (en)
http://linked.open...gbank/containedIn	Apo-Sulfinpyrazone 200 mg Tablet Norpace CR 100 mg 12 Hour Capsule
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B477C-363D-11E5-9242-09173F13E4C5

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