| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # "Link":http://www.medicinenet.com/acetohydroxamic_acid-oral/article.htm (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| - 5-10 hours in patients with normal renal function (en)
|
| http://linked.open...ugbank/indication
| - Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| - Acetohydroxamic Acid (en)
|
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Acetohydroxamic acid (en)
- Lithostat (en)
- AHA (en)
- Acethydroxamsaure (en)
- Acetic acid, oxime (en)
- Acetohydroxamate (en)
- Acetohydroximic acid (en)
- Acetyl hydroxyamino (en)
- Acetylhydroxamic acid (en)
- Cetohyroxamic acid (en)
- Methylhydroxamic acid (en)
- N-Hydroxyacetamide (en)
- Acethydroxamsaeure (en)
- Acide acetohydroxamique (en)
- Acido acetohidroxamico (en)
- Acidum acetohydroxamicum (en)
- N-Acetyl hydroxyacetamide (en)
- N-Acetylhydroxylamine (en)
|
| http://linked.open...drugbank/toxicity
| - Oral, rat: LD<sub>50</sub> = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting. (en)
|
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ynthesisReference
| - Teresio Tamietto, "Process for the preparation of an indole-3-acetohydroxamic acid." U.S. Patent US4186133, issued November, 1971. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...logy/drugbank/pKa
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Well absorbed from the GI tract following oral administration. (en)
|
| http://linked.open.../affectedOrganism
| - Enteric bacteria and other eubacteria (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...strongest-acidic-
| |
| http://linked.open...-strongest-basic-
| |
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