| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) (en)
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| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease). (en)
|
| http://linked.open...bank/manufacturer
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| sameAs
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| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Propylthiouracil is readily absorbed and is extensively metabolized. Approximately 35% of the drug is excreted in the urine, in intact and conjugated forms, within 24 hours. (en)
|
| http://linked.open.../drugbank/synonym
| - Propylthiouracil (en)
- 2,3-dihydro-6-Propyl-2-thioxo-4(1H)-pyrimidinone (en)
- 2-Mercapto-6-propyl-4-pyrimidone (en)
- 2-Mercapto-6-propylpyrimid-4-one (en)
- 2-Thio-4-oxo-6-propyl-1,3-pyrimidine (en)
- 2-Thio-6-propyl-1,3-pyrimidin-4-one (en)
- 4-Propyl-2-thiouracil (en)
- 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione (en)
- 6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (en)
- 6-Propylthiouracil (en)
- 6-Thio-4-propyluracil (en)
- Propiltiouracilo (en)
- Propylthiouracile (en)
- Propylthiouracilum (en)
|
| http://linked.open...drugbank/toxicity
| - Oral, rat: LD<sub>50</sub> = 1250 mg/kg. (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Take at the same time everyday. (en)
|
| http://linked.open...nk/proteinBinding
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Well absorbed following oral administration. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
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