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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Abdel-Ghani NT, Youssef AF, Awady MA: Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco. 2005 May;60(5):419-24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15910814 # Souto-Padron T, Lima AP, Ribeiro Rde O: Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res. 2006 Sep;99(4):317-20. Epub 2006 Apr 13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16612626 # Nounou MM, El-Khordagui LK, Khalafallah N: Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm. 2005 Sep-Oct;62(5):369-79. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16459486 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Cinchocaine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Dibucaine (en)
  • Dibucaine base (en)
  • 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide (en)
  • 2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide (en)
  • 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide (en)
  • 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide (en)
  • CINCHOCAINE (en)
  • Cinchocainum (en)
  • Cincocainio (en)
  • 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide (en)
  • N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide (en)
  • alpha-Butyloxycinchoninic acid diethylethylenediamide (en)
  • alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine (en)
  • 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide (en)
  • 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide (en)
http://linked.open...drugbank/toxicity
  • Subcutaneous LD<sub>50</sub> in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open.../drugbank/mixture
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Dibucaine.htm (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 85-79-0 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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