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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17525040 # Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18039433 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • illicit (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 4.5 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Oxycodone (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability. (en)
http://linked.open...drugbank/packager
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