About: Droperidol

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About: Droperidol Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5224-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5225-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Biphasic distribution. The rapid distribution phase is 1.4 ± 0.5 minutes and the slower distribution phase is 14.3 ± 6.5 minutes. Elimination half-life in adults is 134 ± 13 minutes and may be increased in geriatric patients. In children, it is 101.5 ± 26.4 minutes. (en)
http://linked.open...ugbank/indication	Droperidol is ssed to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures. (en)
http://linked.open...bank/manufacturer	Abraxis pharmaceutical products Astrazeneca lp Camber Pharmaceuticals Inc. Cardinal Health Cipla Ltd. Cobalt Pharmaceuticals Inc. DAVA Pharmaceuticals Akorn inc
sameAs	Droperidol
Title	Droperidol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/bindingdb/50017705 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/chebi/4717 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/chemspider/3056 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/drugbank/DB00450 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/kegg-drug/D00308 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/national-drug-code-directory/11098-010-01 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/pharmgkb/PA449422 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/pubchem-compound/3168 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/pubchem-substance/46505291 http://linked.opendata.cz/resource/drugbank/drug/DB00450/identifier/wikipedia/Droperidol
http://linked.open...mechanismOfAction	The exact mechanism of action is unknown, however, droperidol causes a CNS depression at subcortical levels of the brain, midbrain, and brainstem reticular formation. It may antagonize the actions of glutamic acid within the extrapyramidal system. It may also inhibit cathecolamine receptors and the reuptake of neurotransmiters and has strong central antidopaminergic action and weak central anticholinergic action. It can also produce ganglionic blockade and reduced affective response. The main actions seem to stem from its potent Dopamine(2) receptor antagonism with minor antagonistic effects on alpha-1 adrenergic receptors as well. (en)
http://linked.open...drugbank/packager	Amerisource Health Services Corp. Aidarex Pharmacuticals LLC Apotheca Inc. A-S Medication Solutions LLC Akorn Inc. American Regent Cardinal Health Hospira Inc.
http://linked.open.../drugbank/synonym	Droperidol (en) 1-(1-(3-(P-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone (en) Droperidolo (en) Droperidolum (en) Dropéridol (en) 1-(1-(4-(P-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone (en) 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[D]imidazol-2-one (en) 1-{1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one (en)
http://linked.open...drugbank/toxicity	The intravenous LD<sub>50</sub> of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD<sub>50</sub> of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-24-92
http://linked.open.../drugbank/mixture	Innovar
http://linked.open...ynthesisReference	Janssen, P.A.J. and Gardocki, J.F.; U.S. Patent 3,141,823; July 21, 1964; assigned to Research Laboratorium Dr. C. Janssen NV, Belgium. Januen, P.A.J.; U.S. Patent 3,161,645; December 15,1964: assigned to Research Laboratorium Dr. C. Janssen NV, Belgium. (en)
foaf:page	http://www.drugs.com/cdi/droperidol.html http://www.rxlist.com/cgi/generic3/droperidol.htm
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http://linked.open...l/drug/hasATCCode	Droperidol
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http://linked.open...ugbank/absorption	Completely absorbed following intramuscular administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	548-73-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Dalacin C Palmitate 15 mg/ml Solution Cleocin 600 mg-d5w-galaxy Acetaminophen 325 mg suppository
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5238-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5239-363D-11E5-9242-09173F13E4C5

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