| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products. Lansoprazole has been marketed for many years and is one of several PPI's available. (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
|
| http://linked.open...drugbank/halfLife
| - 1.5 (± 1.0) hours (en)
|
| http://linked.open...ugbank/indication
| - For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H<sub>2</sub>-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H<sup>+</sup>,K<sup>+</sup>)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...y/drugbank/patent
| |
| http://linked.open...outeOfElimination
| - Following single-dose oral administration of PREVACID, virtually no unchanged lansoprazole was excreted in the urine. In one study, after a single oral dose of 14C-lansoprazole, approximately one-third of the administered radiation was excreted in the urine and two-thirds was recovered in the feces. This implies a significant biliary excretion of the lansoprazole metabolites. (en)
|
| http://linked.open.../drugbank/synonym
| - Lansoprazole (en)
- Bamalite (en)
- Lanzopral (en)
- Limpidex (en)
- Monolitum (en)
- Ogastro (en)
- Opiren (en)
- Prevacid (en)
- AG 1749 (en)
- Lansoprazol (en)
- Lansoprazolum (en)
- Lanzol (en)
- Lanzul (en)
|
| http://linked.open...drugbank/toxicity
| - Symptoms of overdose include abdominal pain, nausea and diarrhea. (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take 30-60 minutes before meals. (en)
- Food reduces bioavailabilty, but this has very little clinical impact. (en)
|
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ynthesisReference
| - Clarke Slemon, Bob Macel, "Preparation of omeprazole and lansoprazole." U.S. Patent US5374730, issued December, 1986. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
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