About: Teniposide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B50C4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B50C5-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	5 hours (en)
http://linked.open...ugbank/indication	Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia (en)
http://linked.open...bank/manufacturer	Bristol myers squibb co pharmaceutical research institute
sameAs	Teniposide
Title	Teniposide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/chemspider/31930 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/drugbank/DB00444 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/kegg-compound/C11153 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/kegg-drug/D02698 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/national-drug-code-directory/0015-3075-19 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/pubchem-compound/34698 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/pubchem-substance/46507536 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/pharmgkb/PA451611 http://linked.opendata.cz/resource/drugbank/drug/DB00444/identifier/wikipedia/Teniposide
http://linked.open...mechanismOfAction	The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate. (en)
http://linked.open...drugbank/packager	Bristol-Myers Squibb Co. Mead Johnson and Co.
http://linked.open...outeOfElimination	From 4% to 12% of a dose is excreted in urine as parent drug. Fecal excretion of radioactivity within 72 hours after dosing accounted for 0% to 10% of the dose. (en)
http://linked.open.../drugbank/synonym	Vumon (en) 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) (en) Epidophyllotoxin (en) HSDB 6546 (en) NSC 122819 (en) NSC-122819 (en) Teniposid (en) Teniposido (en) Teniposidum (en) Téniposide (en) VM-26 (en) 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
foaf:page	http://www.drugs.com/cdi/teniposide.html http://www.rxlist.com/cgi/generic2/teniposide.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B50CA-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B50D0-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B50CF-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B50CC-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B50CD-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B50CE-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B50C8-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Teniposide
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B50D6-363D-11E5-9242-09173F13E4C5
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http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B50D1-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B50D2-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B50D4-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B50D3-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B50D5-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	29767-20-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 10.3 mL/min/m2 (en)
http://linked.open...gbank/containedIn	Flovent Hfa 125 mcg/dose Metered Dose Aerosol
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B50DC-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B50DE-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B50DF-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B50DA-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B50DD-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B50CB-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B50D8-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B50D9-363D-11E5-9242-09173F13E4C5

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