About: Betamethasone

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B508F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5090-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5091-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5092-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5093-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5094-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5095-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5096-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5097-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5098-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5099-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B509F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B50A0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B50A1-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	5.6 hours (en)
http://linked.open...ugbank/indication	Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis. (en)
http://linked.open...bank/manufacturer	Glenmark generics inc usa Perrigo new york inc Taro pharmaceuticals usa inc Tolmar inc Schering corp Savage laboratories inc div altana inc Actavis mid atlantic llc E fougera div altana inc Pharmaderm div altana inc Teva pharmaceuticals usa inc Alpharma us pharmaceuticals division Taro pharmaceuticals inc Teva pharmaceuticals usa Watson laboratories inc Connectics corp Tj roaco ltd Pharmafair inc Stat trade inc Schering corp sub schering plough corp Parke davis div warner lambert co Lundbeck inc Altana inc
sameAs	Betamethasone
Title	Betamethasone (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/chebi/3077 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/chemspider/9399 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/drugbank/DB00443 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/kegg-drug/D00244 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/national-drug-code-directory/0085-0942-05 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/pubchem-compound/9782 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/pubchem-substance/46505155 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/pharmgkb/PA164754818 http://linked.opendata.cz/resource/drugbank/drug/DB00443/identifier/wikipedia/Betamethasone
http://linked.open...mechanismOfAction	Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. (en)
http://linked.open...drugbank/packager	Chain Drug CVS Pharmacy Freeda Vitamins Major Pharmaceuticals Mason Distributors Medisca Inc. MSD Frosst Iberica SA Nycomed Inc. Palmetto Pharmaceuticals Inc. Neuman Distributors Inc. Actavis Group Advanced Pharmaceutical Services Inc. American Regent A-S Medication Solutions LLC C.O. Truxton Inc. Clint Pharmaceutical Inc. Contract Pharm Vintage Pharmaceuticals Inc. Darby Dental Supply Co. Inc. Dispensing Solutions Diversified Healthcare Services Inc. DPT Laboratories Ltd. E. Fougera and Co. Faithful Friends Homeopathic Inc. Genesis Pharmaceutical Inc. Breckenridge Pharmaceuticals Lundbeck Inc. Major Pharmaceuticals Nexgen Pharma Inc. Physicians Total Care Inc. Preferred Pharmaceuticals Inc. Qualitest Lannett co inc Rebel Distributors Corp. Whiteworth towne paulsen inc Sandoz Elkins sinn div ah robins co inc Everylife Halsey drug co inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Glaxosmithkline L perrigo co

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