About: Cerivastatin

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About: Cerivastatin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal Rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market. (en)
http://linked.open...generalReferences	# Furberg CD, Pitt B: Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med. 2001;2(5):205-207. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11806796 (en)
http://linked.open...gy/drugbank/group	withdrawn (en)
http://linked.open...drugbank/halfLife	2-3 hours (en)
http://linked.open...ugbank/indication	Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate. (en)
http://linked.open...bank/manufacturer	Bayer pharmaceuticals corp
sameAs	Cerivastatin
Title	Cerivastatin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/bindingdb/18376 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/chebi/3558 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/chemspider/393588 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/drugbank/DB00439 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/kegg-compound/C07966 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/pdb/116 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/pharmgkb/PA448897 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/pubchem-compound/446156 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/pubchem-substance/46505877 http://linked.opendata.cz/resource/drugbank/drug/DB00439/identifier/wikipedia/Cerivastatin
http://linked.open...mechanismOfAction	Cerivastatin competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the hepatic enzyme responsible for converting HMG-CoA to mevalonate. As mevalonate is a precursor of sterols such as cholesterol, this results in a decrease in cholesterol in hepatic cells, upregulation of LDL-receptors, and an increase in hepatic uptake of LDL-cholesterol from the circulation. (en)
http://linked.open...drugbank/packager	Bayer Healthcare
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1340798 http://linked.opendata.cz/resource/drugbank/patent/2057444 http://linked.opendata.cz/resource/drugbank/patent/5177080
http://linked.open...drugbank/toxicity	Rhabdomyolysis, liver concerns (en)
http://linked.open...k/foodInteraction	Take without regard to meals. (en) Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly increase serum levels of this product. (en)
http://linked.open...nk/proteinBinding	More than 99% of the circulating drug is bound to plasma proteins (80% to albumin). (en)
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/mtm/cerivastatin.html http://www.rxlist.com/cgi/generic/cerivastat.htm
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http://linked.open...ugbank/absorption	The mean absolute oral bioavailability 60% (range 39 - 101%). (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	145599-86-6 (en)
http://linked.open...drugbank/category	(en)
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