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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • An antiviral derivative of thymidine used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557) (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Costin D, Dogaru M, Popa AS, Cijevschi I: [Trifluridine therapy in herpetic in keratitis] Rev Med Chir Soc Med Nat Iasi. 2004 Apr-Jun;108(2):409-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15688823 # Kuster P, Taravella M, Gelinas M, Stepp P: Delivery of trifluridine to human cornea and aqueous using collagen shields. CLAO J. 1998 Apr;24(2):122-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9571274 # O'Brien WJ, Taylor JL: Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. Invest Ophthalmol Vis Sci. 1991 Aug;32(9):2455-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1907950 # Overman MJ, Kopetz S, Varadhachary G, Fukushima M, Kuwata K, Mita A, Wolff RA, Hoff P, Xiong H, Abbruzzese JL: Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors. Cancer Invest. 2008 Oct;26(8):794-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18798063 # Hong DS, Abbruzzese JL, Bogaard K, Lassere Y, Fukushima M, Mita A, Kuwata K, Hoff PM: Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors. Cancer. 2006 Sep 15;107(6):1383-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16902987 # Temmink OH, Prins HJ, van Gelderop E, Peters GJ: The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. Br J Cancer. 2007 Jan 15;96(1):61-6. Epub 2006 Dec 19. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17179993 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Approximately 12 to 18 minutes following ophthalmic administration. (en)
http://linked.open...ugbank/indication
  • Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Trifluridine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The mechanism of action of trifluridine has not been fully determined, but appears to involve the inhibition of viral replication. Trifluridine does this by incorporating into viral DNA during replication, which leads to the formation of defective proteins and an increased mutation rate. This drug also reversibly inhibits thymidylate synthetase, an enzyme that is necessary for DNA synthesis. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Trifluridine (en)
  • Trifluoromethyldeoxyuridine (en)
  • Trifluorothymidine (en)
  • Viroptic (en)
  • 5-(Trifluoromethyl)deoxyuridine (en)
  • 5-Trifluoromethyl-2-deoxyuridine (en)
  • F₃T (en)
  • TFT (en)
  • Trifluorothymine deoxyriboside (en)
  • Trifluridin (en)
  • Trifluridina (en)
  • Trifluridinum (en)
http://linked.open...drugbank/toxicity
  • Overdosage by ocular instillation is unlikely because any excess solution should be quickly expelled from the conjunctival sac. Acute overdosage by accidental oral ingestion has not occurred. However, should such ingestion occur, the 75 mg dosage of trifluridine in a 7.5 mL bottle of trifluridine is not likely to produce adverse effects. Single intravenous doses of 1.5 to 30 mg/kg/day in children and adults with neoplastic disease produce reversible bone marrow depression as the only potentially serious toxic effect and only after three to five courses of therapy. The acute oral LD<sub>50</sub> in the mouse and rat was 4379 mg/kg or higher. (en)
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http://linked.open...ugbank/absorption
  • Systemic absorption of trifluridine following therapeutic dosing with trifluridine ophthalmic appears to be negligible. (en)
http://linked.open.../affectedOrganism
  • Human Herpes Virus (en)
http://linked.open...casRegistryNumber
  • 70-00-8 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
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