About: Cidofovir     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 2.4 to 3.2 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Cidofovir (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Cidofovir acts through the selective inhibition of viral DNA polymerase.Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Cidofovir (en)
  • CDV (en)
  • (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine (en)
  • (S)-HPMPC (en)
  • Cidofovir anhydrous (en)
  • Cidofovirum (en)
  • 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (en)
  • 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (en)
  • [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid (en)
  • [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid (en)
  • (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine (en)
  • (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (en)
  • (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid (en)
  • ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid (en)
http://linked.open...drugbank/toxicity
  • Kidney damage, fall in the number of white blood cells, decreased platelets (en)
http://linked.open...umeOfDistribution
  • * 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID] * 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID] (en)
http://linked.open...nk/proteinBinding
  • 6% (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Cidofovir.htm (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • 100% (en)
http://linked.open.../affectedOrganism
  • Human Immunodeficiency Virus (en)
http://linked.open...casRegistryNumber
  • 113852-37-2 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • * 179 +/- 23.1 mL/min/1.73 m2 [WITHOUT PROBENECID] * 148 +/- 38.8 mL/min/1.73 m2 [WITH PROBENECID] (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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