About: Diltiazem

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5BFB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BFC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BFD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BFE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BFF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C00-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C01-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C02-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C03-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C04-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C05-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C06-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C07-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C08-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C09-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C0F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C10-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C11-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C12-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C13-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C14-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C15-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C16-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C17-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C18-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C19-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C1A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C1B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C1C-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3.0 - 4.5 hours (en)
http://linked.open...ugbank/indication	For the treatment of Hypertension (en)
http://linked.open...bank/manufacturer	Biovail laboratories inc PCA LLC Pharmaceutical Association Apotex inc Pharmaceutical Utilization Management Program VA Inc. Kv pharmaceutical co Mylan pharmaceuticals inc Alra laboratories inc Apotex inc etobicoke site Precision Dose Inc. Biovail laboratories international srl Apotex inc richmond hill Baxter healthcare corp anesthesia and critical care Ranbaxy Laboratories Hospira inc International medication systems ltd Remedy Repack Baxter International Inc. Apothecon inc div bristol myers squibb Sandoz Ivax pharmaceuticals inc sub teva pharmaceuticals usa Bioniche Pharma Advanced Pharmaceutical Services Inc.
sameAs	Diltiazem
Title	Diltiazem (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/bindingdb/50004704 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/chebi/101278 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/chemspider/35850 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/drugbank/DB00343 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/kegg-compound/C06958 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/national-drug-code-directory/54868-4970-0 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/pharmgkb/PA449334 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/pubchem-compound/39186 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/pubchem-substance/46505667 http://linked.opendata.cz/resource/drugbank/drug/DB00343/identifier/wikipedia/Diltiazem
http://linked.open...mechanismOfAction	Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue. (en)
http://linked.open...drugbank/packager	Abbott Laboratories Ltd. Pharmaceutical Utilization Management Program VA Inc. Advanced Pharmaceutical Services Inc. Akorn Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Biovail Pharmaceuticals Bracco Diagnostics Inc. Bryant Ranch Prepack BTA Pharmaceuticals Cardinal Health Caremark LLC Comprehensive Consultant Services Inc. Corepharma LLC Apotheca Inc. C.O. Truxton Inc. Carlisle Laboratories Inc. Dispensing Solutions Diversified Healthcare Services Inc.

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