About: Floxuridine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5445-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion). (en)
http://linked.open...bank/manufacturer	App pharmaceuticals llc Bradley Pharmaceuticals Inc. Barr laboratories inc
sameAs	Floxuridine
Title	Floxuridine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/bindingdb/50042595 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/chebi/60761 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/chemspider/5586 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/drugbank/DB00322 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/kegg-compound/C11736 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/kegg-drug/D04197 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/national-drug-code-directory/61703-331-09 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/pharmgkb/PA449652 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/pubchem-compound/5790 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/pubchem-substance/46508645 http://linked.opendata.cz/resource/drugbank/drug/DB00322/identifier/wikipedia/Floxuridine
http://linked.open...mechanismOfAction	Floxuridine is rapidly catabolized to 5-fluorouracil, which is the active form of the drug. The primary effect is interference with DNA synthesis and to a lesser extent, inhibition of RNA formation through the drug's incorporation into RNA, thus leading to the production of fraudulent RNA. Fluorouracil also inhibits uracil riboside phophorylase, which prevents the utilization of preformed uracil in RNA synthesis. As well, the monophosphate of floxuridine, 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) inhibits the enzyme thymidylate synthetase. This leads to the inhibition of methylation of deoxyuridylic acid to thymidylic acid, thus interfering with DNA synthesis. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Atlantic Biologicals Corporation Baroli Ani pharmaceuticals inc Bio Pharm Inc.
http://linked.open...outeOfElimination	The drug is excreted intact and as urea, fluorouracil, a-fluoro-bureidopropionic acid, dihydrofluorouracil, a-fluoro-b-guanidopropionic acid and a-fluoro-b-alanine in the urine; it is also expired as respiratory carbon dioxide. (en)
http://linked.open.../drugbank/synonym	Floxuridine (en) FUDR (en) 5FDU (en) Deoxyfluorouridine (en) Floxuridin (en) Fluorodeoxyuridine (en) Fluoruridine Deoxyribose (en) 5-Fluorodeoxyuridine (en) 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil (en) 1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil (en) 1beta-D-2'-Deoxyribofuranosyl-5-flurouracil (en) 2'-Deoxy-5-fluorouridine (en) 5-Fluoro-2-desoxyuridine (en) 5-Fluorouracil 2'-deoxyriboside (en) 5-Fluorouracil deoxyriboside (en) FdU (en) Floxiridina (en) Floxuridinum (en) beta-5-Fluoro-2'-deoxyuridine (en)
http://linked.open...drugbank/toxicity	Oral, rat LD<sub>50</sub>: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis). (en)
http://linked.open...ynthesisReference	U.S. Patent 3,041,335. (en)
foaf:page	http://www.drugs.com/cdi/floxuridine.html http://www.rxlist.com/cgi/generic2/floxuridine.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	50-91-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Fudr 500 mg vial Floxuridine 500 mg vial
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