About: Capreomycin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • Used in the treatment of tuberculosis in combination with other drugs. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Capreomycin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours. (en)
http://linked.open...drugbank/toxicity
  • Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD<sub>50</sub>) in mice was 514 mg/kg. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • Michael George Thomas, Elizabeth Anne Felnagle, Michelle Renee Rondon, Andrew David Berti, "Heterologous Production of Capreomycin and Generation of New Capreomycin Derivatives Through Metabolic Engineering." U.S. Patent US20090104658, issued April 23, 2009. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
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http://linked.open...ugbank/absorption
  • Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally. (en)
http://linked.open.../affectedOrganism
  • Enteric bacteria and other eubacteria (en)
http://linked.open...casRegistryNumber
  • 11003-38-6 (en)
http://linked.open...gbank/containedIn
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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