About: Chlorambucil     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, Hines J, Threatte GA, Larson RA, Cheson BD, Schiffer CA: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000 Dec 14;343(24):1750-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11114313 # Yang K, Tan J, Wu T: Alkylating agents for Waldenstrom's macroglobulinaemia. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006719. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19160296# Foon KA, Hallek MJ: Changing paradigms in the treatment of chronic lymphocytic leukemia. Leukemia. 2010 Mar;24(3):500-11. Epub 2009 Dec 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20033051 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 1.5 hours (en)
http://linked.open...ugbank/indication
  • For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Chlorambucil (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard. The pharmacokinetic data suggests that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion. (en)
http://linked.open.../drugbank/synonym
  • CHLORAMBUCIL (en)
  • Ambochlorin (en)
  • Leukeran (en)
  • Chloraminophen (en)
  • Phenylbutyric Acid Nitrogen Mustard (en)
  • N,N-Di-2-chloroethyl-gamma-P-aminophenylbutyric acid (en)
  • 4-(P-Bis(beta-chloroethyl)aminophenyl)butyric acid (en)
  • 4-(p-bis(β-chloroethyl)aminophenyl)butyric acid (en)
  • 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid (en)
  • N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid (en)
  • gamma-[P-Di(2-chloroethyl)aminophenyl]butyric acid (en)
  • γ-[p-di(2-chloroethyl)aminophenyl]butyric acid (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Drink liberally. (en)
  • Food reduces bioavailability. (en)
  • Take on an empty stomach. (en)
  • Echinacea should be used with caution, if at all, in patients receiving therapeutic immunosuppressants. Monitor for reduced efficacy of the immunosuppressant during concomitant use. (en)
http://linked.open...nk/proteinBinding
  • 99% (en)
http://linked.open...ynthesisReference
  • Phillips, A. P. and Mentha, J.W.; U.S.Patent 3,046,301; July 24, 1962; assigned to Burroughs Wellcome & Co. (U.S.A.) Inc. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 305-03-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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