About: Isradipine

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About: Isradipine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B447F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4480-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Fletcher H, Roberts G, Mullings A, Forrester T: An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia. J Obstet Gynaecol. 1999 May;19(3):235-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15512286 # Ganz M, Mokabberi R, Sica DA: Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study. J Clin Hypertens (Greenwich). 2005 Apr;7(4 Suppl 1):27-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15858400 # Hattori T, Wang PL: Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts. Eur J Med Res. 2006 Mar 27;11(3):93-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16751108 # Johnson BA, Roache JD, Ait-Daoud N, Wallace C, Wells L, Dawes M, Wang Y: Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects. Int J Neuropsychopharmacol. 2005 Jun;8(2):203-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15850499 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	8 hours (en)
http://linked.open...ugbank/indication	For the management of mild to moderate essential hypertension. It may be used alone or concurrently with thiazide-type diuretics. (en)
http://linked.open...bank/manufacturer	Pharmaceutical Utilization Management Program VA Inc. Actavis totowa llc Advanced Pharmaceutical Services Inc. Akorn Inc.
sameAs	Isradipine
Title	Isradipine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/chemspider/3652 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/drugbank/DB00270 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/kegg-drug/D00349 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/national-drug-code-directory/0173-0784-01 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/pharmgkb/PA450131 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/pubchem-compound/3784 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/pubchem-substance/46505034 http://linked.opendata.cz/resource/drugbank/drug/DB00270/identifier/wikipedia/Isradipine
http://linked.open...mechanismOfAction	Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in <i>Homo sapiens</i>: L-, N-, P/Q-, R- and T-type. CCBs target L-type calcium channels, the major channel in muscle cells that mediates contraction. Similar to other DHP CCBs, isradipine binds directly to inactive calcium channels stabilizing their inactive conformation. Since arterial smooth muscle depolarizations are longer in duration than cardiac muscle depolarizations, inactive channels are more prevalent in smooth muscle cells. Alternative splicing of the alpha-1 subunit of the channel gives isradipine additional arterial selectivity. At therapeutic sub-toxic concentrations, isradipine has little effect on cardiac myocytes and conduction cells. (en)
http://linked.open...drugbank/packager	Actavis Group Alza Corp. Amerisource Health Services Corp. Caremark LLC Cobalt Pharmaceuticals Inc. GlaxoSmithKline Inc. Barr Pharmaceuticals Cardinal Health GD Searle LLC Innovative Manufacturing and Distribution Services Inc. Hospira inc Pfizer Inc.
http://linked.open...outeOfElimination	Approximately 60% to 65% of an administered dose is excreted in the urine and 25% to 30% in the feces. (en)
http://linked.open.../drugbank/synonym	Dynacirc (en) Isradipino (en) Isradipinum (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include lethargy, sinus tachycardia, and transient hypotension. Significant lethality was observed in mice given oral doses of over 200 mg/kg and rabbits given about 50 mg/kg of isradipine. Rats tolerated doses of over 2000 mg/kg without effects on survival. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/24-28-08
http://linked.open...nk/proteinBinding	95% (en)
foaf:page	http://www.drugs.com/cdi/isradipine.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dyn1152.shtml http://www.rxlist.com/cgi/generic2/israd.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4485-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B448B-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B448A-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4487-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4488-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4489-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Isradipine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4491-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Isradipine is 90%-95% absorbed and is subject to extensive first-pass metabolism, resulting in a bioavailability of about 15%-24%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	75695-93-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Isradipine 2.5 mg capsule Cyclosporine a powder CycloSPORINE Modified 30 25 mg capsule Box Carbocaine 2% vial Dynacirc cr 5 mg tablet DynaCirc CR 5 mg 24 Hour tablet Carbocaine 1% vial DynaCirc CR 10 mg 24 Hour tablet
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4496-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B4494-363D-11E5-9242-09173F13E4C5
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http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4486-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4493-363D-11E5-9242-09173F13E4C5

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