About: Ropinirole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson's disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4411-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4412-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4413-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4414-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4415-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4416-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4417-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4418-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4419-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B441F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4420-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4421-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4422-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4423-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4424-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4425-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4426-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4427-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4428-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4429-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B442A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B442B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B442C-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	6 hours (en)
http://linked.open...ugbank/indication	For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome. (en)
http://linked.open...bank/manufacturer	Kaiser Foundation Hospital Glaxosmithkline A-S Medication Solutions LLC Bryant Ranch Prepack Diversified Healthcare Services Inc. Eli Lilly & Co. Lake Erie Medical and Surgical Supply Lilly Del Caribe Inc. Nucare Pharmaceuticals Inc. Physicians Total Care Inc. Rebel Distributors Corp.
sameAs	Ropinirole
Title	Ropinirole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/chebi/8888 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/chemspider/4916 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/drugbank/DB00268 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/kegg-compound/C07564 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/national-drug-code-directory/0007-4890-20 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/pubchem-compound/5095 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/pubchem-substance/46507918 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/pharmgkb/PA164749035 http://linked.opendata.cz/resource/drugbank/drug/DB00268/identifier/wikipedia/Ropinirole
http://linked.open...mechanismOfAction	Ropinirole binds the dopamine receptors D<sub>3</sub> and D<sub>2</sub>. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum. (en)
http://linked.open...drugbank/packager	Amerisource Health Services Corp. A-S Medication Solutions LLC Atlantic Biologicals Corporation Bryant Ranch Prepack Pharmaceutical Utilization Management Program VA Inc. American Regent American Therapeutics Medicines Inc. Bioniche Pharma Claris Lifesciences Inc. DSM Corp. Heritage Pharmaceuticals Innoviant Pharmacy Inc. Kaiser Foundation Hospital Actavis mid atlantic llc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Mckesson Corp. Murfreesboro Pharmaceutical Nursing Supply Mylan Nucare Pharmaceuticals Inc. PD-Rx Pharmaceuticals Inc. Physicians Total Care Inc. Rebel Distributors Corp. Resource Optimization and Innovation LLC Roxane Labs Stat Rx Usa Axcan Pharma Inc. Confab Laboratories Inc. Eurand Pharmaceuticals Inc. Global Pharmaceuticals
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5422123
http://linked.open...outeOfElimination	Ropinirole is extensively metabolized by the liver to inactive metabolites, and less than 10% of the administered dose is excreted as unchanged drug in urine. (en)
http://linked.open.../drugbank/synonym	Ropinirole (en) Ropinirol (en) Ropinirolum (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting. (en)
http://linked.open...umeOfDistribution	* 7.5 L/kg * 525 L (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-36-20-08
http://linked.open...nk/proteinBinding	40% bound to plasma proteins with a blood-to-plasma ratio of 1:1. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	"DrugSyn.org":http://www.drugsyn.org/Ropinirole.htm (en)
foaf:page	http://www.drugs.com/cdi/ropinirole.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/req1372.shtml http://www.rxlist.com/cgi/generic/ropinirole.htm

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