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rdf:type
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http://linked.open...gbank/description
| - An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. [PubChem] (en)
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http://linked.open...generalReferences
| - # Cullen JJ, Hinkhouse MM, Grady M, Gaut AW, Liu J, Zhang YP, Weydert CJ, Domann FE, Oberley LW: Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res. 2003 Sep 1;63(17):5513-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14500388 # Mironov AA, Colanzi A, Polishchuk RS, Beznoussenko GV, Mironov AA Jr, Fusella A, Di Tullio G, Silletta MG, Corda D, De Matteis MA, Luini A: Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport. Eur J Cell Biol. 2004 Jul;83(6):263-79. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15511084 # Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz LO: Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication. Arch Biochem Biophys. 2005 Feb 15;434(2):241-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15639223 # Thanos CG, Liu Z, Reineke J, Edwards E, Mathiowitz E: Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride. Pharm Res. 2003 Jul;20(7):1093-100. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12880296 (en)
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http://linked.open...gy/drugbank/group
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http://linked.open...ugbank/indication
| - For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis. (en)
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http://linked.open...bank/manufacturer
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. (en)
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http://linked.open.../drugbank/synonym
| - Dicoumarol (en)
- Dicumarol (en)
- 3,3'-Methylen-bis(4-hydroxy-cumarin) (en)
- 3,3'-Methylene-bis(4-hydroxycoumarine) (en)
- 3,3'-Methylenebis(4-hydroxy-1,2-benzopyrone) (en)
- 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one) (en)
- 3,3'-Methylenebis(4-hydroxycoumarin) (en)
- Bis(4-hydroxycoumarin-3-yl)methane (en)
- Dicoumarolum (en)
- bis-3,3'-(4-hydroxycoumarinyl)methane (en)
- bis-hydroxycoumarin (en)
- di-(4-hydroxy-3-coumarinyl)methane (en)
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http://linked.open...drugbank/toxicity
| - LD<sub>50</sub>=233 mg/kg (orally in mice); LD<sub>50</sub>=250 mg/kg (orally in rats) (en)
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...gy/drugbank/InChI
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...noisotopic-Weight
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http://linked.open...y/drugbank/SMILES
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http://linked.open.../Water-Solubility
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http://linked.open...ogy/drugbank/logP
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http://linked.open...ogy/drugbank/logS
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http://linked.open...l/drug/hasATCCode
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http://linked.open...nd-Acceptor-Count
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http://linked.open...-Bond-Donor-Count
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http://linked.open...drugbank/InChIKey
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http://linked.open...urface-Area--PSA-
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http://linked.open...nk/Polarizability
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http://linked.open...bank/Refractivity
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http://linked.open...atable-Bond-Count
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http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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http://linked.open...casRegistryNumber
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http://linked.open...drugbank/category
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http://linked.open...k/Bioavailability
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http://linked.open...bank/Ghose-Filter
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http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...ank/Melting-Point
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http://linked.open...k/Number-of-Rings
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http://linked.open...siological-Charge
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http://linked.open...bank/Rule-of-Five
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http://linked.open...tional-IUPAC-Name
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http://linked.open...strongest-acidic-
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http://linked.open...-strongest-basic-
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