About: Mesalazine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed) (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # "Link":http://en.wikipedia.org/wiki/Mesalamine (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • The mean elimination half-life was 5 hours for 5-ASA and six hours for N-acetyl-5-ASA following the initial dose. At steady state, the mean elimination half-life was seven hours for both 5-ASA and N-acetyl-5-ASA. (en)
http://linked.open...ugbank/indication
  • For the treatment of active ulcerative proctitis. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Mesalazine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Although the mechanism of action of mesalazine is not fully understood, it appears to be topical rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open...outeOfElimination
  • Approximately 28% of the mesalamine in Asacol tablets is absorbed after oral ingestion, leaving the remainder available for topical action and excretion in the feces. It is excreted mainly by the kidney as N-acetyl-5-aminosalicylic acid. (en)
http://linked.open.../drugbank/synonym
  • Mesalazine (en)
  • Asacol (en)
  • Asacolitin (en)
  • Canasa (en)
  • Claversal (en)
  • Fisalamine (en)
  • Lixacol (en)
  • Mesasal (en)
  • Pentasa (en)
  • Rowasa (en)
  • Salofalk (en)
  • 5-ASA (en)
  • 5-aminosalicylic acid (en)
  • Mesalamine (en)
  • 3-carboxy-4-hydroxyaniline (en)
  • Iialda (en)
  • Mesalazina (en)
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