About: Phentermine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]. Some common brand names for phentermine are Adipex-P® and Suprenza™. Phentermine is also available in combination medications such as Qsymia®. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B55F7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55F8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55F9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55FA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55FB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55FC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55FD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B55FE-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Bray GA: A concise review on the therapeutics of obesity. Nutrition. 2000 Oct;16(10):953-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11054601 # Nelson DL, Gehlert DR: Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. 2006 Feb;29(1):49-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16622292 (en)
http://linked.open...gy/drugbank/group	approved (en) illicit (en)
http://linked.open...drugbank/halfLife	16 to 31 hours (en)
http://linked.open...ugbank/indication	For the treatment and management of obesity. (en)
http://linked.open...bank/manufacturer	Baxter healthcare corp anesthesia critical care Doctor Reddys Laboratories Ltd. Eon Labs Ferndale laboratories inc H.J. Harkins Co. Inc. Heartland Repack Services LLC Abc holding corp Sandoz Actavis totowa llc Amerifit Inc. Bio Pharm Inc. Actavis mid atlantic llc Dispensing Solutions G & W Labs G Pohl Boskamp GmbH and Co. KG International Laboratories Inc. Iroko pharmaceuticals llc 3m co Able laboratories inc Avanthi inc Inwood laboratories inc sub forest laboratories inc Prescription Dispensing Service Inc. Johnson and johnson medical inc Actavis elizabeth llc Caraco pharmaceutical laboratories ltd Sandoz A-S Medication Solutions LLC Becton dickinson surgical system Ben Venue Laboratories Inc.
sameAs	Phentermine
Title	Phentermine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/chebi/8080 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/chemspider/4607 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/drugbank/DB00191 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/kegg-compound/C07438 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/kegg-drug/D05458 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/national-drug-code-directory/0527-1445-01 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/pubchem-compound/4771 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/pubchem-substance/46508515 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/pharmgkb/PA164748099 http://linked.opendata.cz/resource/drugbank/drug/DB00191/identifier/wikipedia/Phentermine
http://linked.open...mechanismOfAction	Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage. (en)
http://linked.open...drugbank/packager	Apotheca Inc. A-S Medication Solutions LLC Blenheim Pharmacal Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotheca Inc. Sandoz A-S Medication Solutions LLC Bedford Labs Bracco diagnostics inc Cardinal Health Caremark LLC Central Texas Community Health Centers Comprehensive Consultant Services Inc. DHHS Program Support Center Supply Service Center Direct Dispensing Inc. Dispensing Solutions Emcure Pharmaceuticals Ltd. Endo Pharmaceuticals Inc. 3M Health Care Adrian Pharmaceuticals LLC Advanced Pharmaceutical Services Inc. Aplicare Inc. Apotex Inc. AR Medicom Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Cao Group Inc. Colgate Oral Darby Dental Supply Co. Inc. Dental Technologies Inc. DENTSPLY International Dexcel Ltd. Diversified Healthcare Services Inc. Germiphene Corp. Cornerstone Pharmacy Altura Pharmaceuticals Inc. Abraxis pharmaceutical products Apotheca Inc. A-S Medication Solutions LLC Blenheim Pharmacal Bryant Ranch Prepack Cardinal Health

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